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    stx1b syntaxin 1B [ Danio rerio (zebrafish) ]

    Gene ID: 58038, updated on 4-Jan-2025

    Summary

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    Official Symbol
    stx1bprovided by ZNC
    Official Full Name
    syntaxin 1Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000330-4
    See related
    Ensembl:ENSDARG00000000503 AllianceGenome:ZFIN:ZDB-GENE-000330-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb76h10; zgc:92909; syntaxin1b; wu:fb76h10
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in exocytosis; intracellular protein transport; and vesicle docking. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system and presynaptic active zone membrane. Is expressed in nervous system and trigeminal placode. Used to study epilepsy. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Orthologous to human STX1B (syntaxin 1B). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See stx1b in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (5163938..5254380, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (5247452..5337894, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 3b Neighboring gene si:dkey-89b17.4 Neighboring gene perforin 1.3 Neighboring gene si:dkeyp-113d7.10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model. Zheng YM, et al. Front Mol Neurosci, 2018. PMID 30534049, Free PMC Article
    2. Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes. Schubert J, et al. Nat Genet, 2014 Dec. PMID 25362483
    3. Proinflammatory Caspase A Activation and an Antiviral State Are Induced by a Zebrafish Perforin after Possible Cellular and Functional Diversification from a Myeloid Ancestor. Varela M, et al. J Innate Immun, 2016. PMID 26087843, Free PMC Article
    4. Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Pan W, et al. Sci Rep, 2022 Jun 16. PMID 35710785, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131523.1 → NP_571598.1  syntaxin-1B

      See identical proteins and their annotated locations for NP_571598.1

      Status: PROVISIONAL

      Source sequence(s)
      AF229154
      UniProtKB/TrEMBL
      Q9I9P6
      Related
      ENSDARP00000076389.5, ENSDART00000081951.7
      Conserved Domains (3) summary
      cd00179
      Location:29 → 180
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15880
      Location:190 → 258
      SNARE_syntaxin1; SNARE motif of syntaxin 1
      pfam00804
      Location:29 → 226
      Syntaxin; Syntaxin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      5163938..5254380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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