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    pax8 paired box 8 [ Danio rerio (zebrafish) ]

    Gene ID: 60637, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pax8provided by ZNC
    Official Full Name
    paired box 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-001030-3
    See related
    Ensembl:ENSDARG00000015879 AllianceGenome:ZFIN:ZDB-GENE-001030-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification involved in pronephros development; otic placode formation; and peripheral nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including endocrine system; mesoderm; nervous system; neurogenic field; and pronephros. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See pax8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (72407498..72416098, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (71634624..71643126, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene WW domain binding protein 1 Neighboring gene thioredoxin domain-containing protein 2-like Neighboring gene PH and SEC7 domain-containing protein 4 Neighboring gene zinc finger protein 154 Neighboring gene hydroxycarboxylic acid receptor 2-

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Formation of the spinal network in zebrafish determined by domain-specific pax genes. Ikenaga T, et al. J Comp Neurol, 2011 Jun 1. PMID 21452218, Free PMC Article
    2. Transgenic line with gal4 insertion useful to study morphogenesis of craniofacial perichondrium, vascular endothelium-associated cells, floor plate, and dorsal midline radial glia during zebrafish development. Nakayama S, et al. Dev Growth Differ, 2012 Feb. PMID 22348745, Free PMC Article
    3. Unraveling molecular targets of bisphenol A and S in the thyroid gland. Berto-Júnior C, et al. Environ Sci Pollut Res Int, 2018 Sep. PMID 30006815
    4. Vitamin D receptor deficiency impairs inner ear development in zebrafish. Kwon HJ. Biochem Biophys Res Commun, 2016 Sep 16. PMID 27526995
    5. Bisphenol A interferes with thyroid specific gene expression. Gentilcore D, et al. Toxicology, 2013 Feb 8. PMID 23238275

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pax2a and Pax8 regulate cell differentiation during sensory placode formation
      Title: Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation.
    2. pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1, a necessary step for further otic development
      Title: Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24.
    3. Pax2a and Pax8 are the main effectors downstream of Fgf signals in ear formation
      Title: Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors.
    4. pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate
      Title: Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification involved in pronephros development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within otic placode formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otic placode formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peripheral nervous system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    paired box protein Pax-8
    Names
    paired box gene 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      72407498..72416098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476713.2 → XP_021332388.1  paired box protein Pax-8 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PZA2
      Conserved Domains (2) summary
      smart00351
      Location:2 → 115
      PAX; Paired Box domain
      pfam12403
      Location:326 → 420
      Pax2_C; Paired-box protein 2 C terminal

    2. XM_017356403.3 → XP_017211892.1  paired box protein Pax-8 isoform X3

      UniProtKB/TrEMBL
      A0A8M6Z787

    3. XM_001339857.9 → XP_001339893.5  paired box protein Pax-8 isoform X1

      UniProtKB/TrEMBL
      A0A8M1PSE2, F1Q9Q9
      Related
      ENSDARP00000033414.7, ENSDART00000029014.8
      Conserved Domains (2) summary
      smart00351
      Location:8 → 132
      PAX; Paired Box domain
      pfam12403
      Location:343 → 437
      Pax2_C; Paired-box protein 2 C terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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