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    hic1l hypermethylated in cancer 1 like [ Danio rerio (zebrafish) ]

    Gene ID: 30771, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hic1lprovided by ZNC
    Official Full Name
    hypermethylated in cancer 1 likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030620-1
    See related
    Ensembl:ENSDARG00000045660 AllianceGenome:ZFIN:ZDB-GENE-030620-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hic1; hzp1; zfHIC1a; wu:fa03g10; zgc:153128; etID142640.25
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See hic1l in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (25562797..25575717, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (25469487..25480639, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene PHD and ring finger domains 1 Neighboring gene interferon regulatory factor 7 Neighboring gene TBC1 domain family, member 2B Neighboring gene calcium and integrin binding family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1. Bertrand S, et al. Biochim Biophys Acta, 2004 Apr 16. PMID 15093138
    2. Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. Deltour S, et al. Biochem Biophys Res Commun, 2001 Sep 21. PMID 11554746
    3. Isolation and embryonic expression of the novel mouse gene Hic1, the homologue of HIC1, a candidate gene for the Miller-Dieker syndrome. Grimm C, et al. Hum Mol Genet, 1999 Apr. PMID 10072440
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153128

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hypermethylated in cancer 1 like
    Names
    hypermethylated in cancer zinc finger/POZ-domain 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131483.2 → NP_571558.2  hypermethylated in cancer 1 like

      Status: VALIDATED

      Source sequence(s)
      AL928892, EH554811
      UniProtKB/TrEMBL
      A0A8M9PML7, A9JT69
      Related
      ENSDARP00000067137.4, ENSDART00000067138.5
      Conserved Domains (4) summary
      sd00017
      Location:374 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372 → 394
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:18 → 119
      BTB; BTB/POZ domain
      pfam13465
      Location:414 → 439
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      25562797..25575717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470449.2 → XP_021326124.1  hypermethylated in cancer 1 like isoform X1

      UniProtKB/TrEMBL
      A0A8M9PML7, A9JT69
      Conserved Domains (4) summary
      sd00017
      Location:374 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372 → 394
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:18 → 119
      BTB; BTB/POZ domain
      pfam13465
      Location:414 → 439
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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