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    hadhaa hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a [ Danio rerio (zebrafish) ]

    Gene ID: 553401, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hadhaaprovided by ZNC
    Official Full Name
    hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031222-5
    See related
    Ensembl:ENSDARG00000057128 AllianceGenome:ZFIN:ZDB-GENE-031222-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hadha; cb1055; im:7136067; wu:fa14c08
    Summary
    Predicted to enable enoyl-CoA hydratase activity and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Acts upstream of or within response to bacterium. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial fatty acid beta-oxidation multienzyme complex. Is expressed in several structures, including midbrain; midbrain neural tube; musculature system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in mitochondrial trifunctional protein deficiency and steatotic liver disease. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hadhaa in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (47953047..47984899)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (48521830..48555177)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488700 Neighboring gene transcription factor AP-2 delta (activating enhancer binding protein 2 delta) Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene GRB2 associated, regulator of MAPK1-like Neighboring gene prolyl endopeptidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fish Oil Suppresses Body Fat Accumulation in Zebrafish. Meguro S, et al. Zebrafish, 2018 Feb. PMID 29185886
    2. Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. Rawls JF, et al. Cell, 2006 Oct 20. PMID 17055441, Free PMC Article
    3. Dynamics of Zebrafish Heart Regeneration Using an HPLC-ESI-MS/MS Approach. Ma D, et al. J Proteome Res, 2018 Mar 2. PMID 29369637
    4. Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. Kanther M, et al. Gastroenterology, 2011 Jul. PMID 21439961, Free PMC Article
    5. Proteomic analysis of male zebrafish livers chronically exposed to perfluorononanoic acid. Zhang W, et al. Environ Int, 2012 Jul. PMID 21481936

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-CoA hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enoyl-CoA hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial fatty acid beta-oxidation multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial fatty acid beta-oxidation multienzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a
    Names
    hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit a
    hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein)
    hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit a
    NP_001098746.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105276.1 → NP_001098746.1  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a

      See identical proteins and their annotated locations for NP_001098746.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115212
      UniProtKB/TrEMBL
      A0A8M1NEM2, A7YT47
      Related
      ENSDARP00000074186.5, ENSDART00000079734.6
      Conserved Domains (4) summary
      cd06558
      Location:39 → 249
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      TIGR02441
      Location:25 → 760
      fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial
      pfam00725
      Location:542 → 637
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:361 → 539
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      47953047..47984899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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