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    slc38a4 solute carrier family 38 member 4 [ Danio rerio (zebrafish) ]

    Gene ID: 449771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc38a4provided by ZNC
    Official Full Name
    solute carrier family 38 member 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-14
    See related
    Ensembl:ENSDARG00000018149 AllianceGenome:ZFIN:ZDB-GENE-041010-14
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fd51c05; zgc:103694; zgc:113830
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in liver. Orthologous to human SLC38A4 (solute carrier family 38 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slc38a4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (1516674..1566572)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (1667371..1717259)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 35-14 Neighboring gene TUB like protein 3 Neighboring gene uncharacterized LOC110439353 Neighboring gene solute carrier family 38 member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of developmental toxicity. Fu J, et al. Environ Sci Technol, 2013 Sep 17. PMID 23919627
    2. Effects of β-diketone antibiotic mixtures on behavior of zebrafish (Danio rerio). Wang X, et al. Chemosphere, 2016 Feb. PMID 26595314
    3. Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface. Hunter MV, et al. Nat Commun, 2021 Nov 1. PMID 34725363, Free PMC Article
    4. Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity. Jima DD, et al. Mol Immunol, 2009 Apr. PMID 19200601, Free PMC Article
    5. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium-coupled neutral amino acid transporter 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005944.2 → NP_001005944.2  sodium-coupled neutral amino acid transporter 4

      Status: VALIDATED

      Source sequence(s)
      AL929171
      UniProtKB/TrEMBL
      A0A8M6YZH0, Q5SPB0
      Related
      ENSDARP00000067445.4, ENSDART00000067446.6
      Conserved Domains (3) summary
      COG0814
      Location:68 → 520
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam14357
      Location:3 → 90
      DUF4404; Domain of unknown function (DUF4404)
      cl00456
      Location:72 → 525
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      1516674..1566572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017355001.3 → XP_017210490.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YZH0, Q5SPB0
      Conserved Domains (3) summary
      COG0814
      Location:68 → 520
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam14357
      Location:3 → 90
      DUF4404; Domain of unknown function (DUF4404)
      cl00456
      Location:72 → 525
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_017355003.3 → XP_017210492.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YZH0, Q5SPB0
      Conserved Domains (3) summary
      COG0814
      Location:68 → 520
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam14357
      Location:3 → 90
      DUF4404; Domain of unknown function (DUF4404)
      cl00456
      Location:72 → 525
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_017355004.3 → XP_017210493.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YZH0, Q5SPB0
      Conserved Domains (3) summary
      COG0814
      Location:68 → 520
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam14357
      Location:3 → 90
      DUF4404; Domain of unknown function (DUF4404)
      cl00456
      Location:72 → 525
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. XM_017355002.3 → XP_017210491.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M6YZH0, Q5SPB0
      Conserved Domains (3) summary
      COG0814
      Location:68 → 520
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      pfam14357
      Location:3 → 90
      DUF4404; Domain of unknown function (DUF4404)
      cl00456
      Location:72 → 525
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version

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