ppp2r5ea protein phosphatase 2, regulatory subunit B', epsilon isoform a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppp2r5eaprovided by ZNC
Official Full Name: protein phosphatase 2, regulatory subunit B', epsilon isoform aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030904-7
See related: Ensembl:ENSDARG00000015474 AllianceGenome:ZFIN:ZDB-GENE-030904-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wdb1; ppp2r5e2; zgc:85613
Summary: Predicted to enable protein phosphatase activator activity. Predicted to act upstream of or within signal transduction. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in female organism. Orthologous to human PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (20231638..20270173, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (20331965..20370548, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In zebrafish, two wdb (protein phosphatase 2, regulatory subunit B (B56)) homologs are required for convergent extension during gastrulation.
Title: Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein phosphatase 2, regulatory subunit B', epsilon isoform a

Names: protein phosphatase 2, regulatory subunit B (B56) 2; widerborst 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194415.2 → NP_919396.1 protein phosphatase 2, regulatory subunit B', epsilon isoform a

See identical proteins and their annotated locations for NP_919396.1

Status: PROVISIONAL

Source sequence(s)

BC078645

UniProtKB/TrEMBL

B2GS22, F6P4W6, Q8AXX6

Related

ENSDARP00000016494.9, ENSDART00000009356.11

Conserved Domains (2) summary

PLN00122
Location:359 → 453

PLN00122; serine/threonine protein phosphatase 2A; Provisional

pfam01603
Location:55 → 453

B56; Protein phosphatase 2A regulatory B subunit (B56 family)