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    aoc2 amine oxidase copper containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 541429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aoc2provided by ZNC
    Official Full Name
    amine oxidase copper containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-133
    See related
    Ensembl:ENSDARG00000014646 AllianceGenome:ZFIN:ZDB-GENE-050320-133
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    aoc3; fa94a08; fe14c05; wu:fa94a08; wu:fe14c05; zgc:113006
    Summary
    Predicted to enable copper ion binding activity; primary methylamine oxidase activity; and quinone binding activity. Predicted to be involved in amine metabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AOC2 (amine oxidase copper containing 2) and AOC3 (amine oxidase copper containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See aoc2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (32924186..32927605, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (32792472..32795891, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene K(lysine) acetyltransferase 7a Neighboring gene glucose-6-phosphatase catalytic subunit 1b Neighboring gene NBR1 autophagy cargo receptor b Neighboring gene caspase 6b.1, apoptosis-related cysteine peptidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hydroxycoumarin efficiently inhibits spring viraemia of carp virus infection in vitro and in vivo. Liu L, et al. Zool Res, 2020 Jul 18. PMID 32390373, Free PMC Article
    2. Comparative transcriptome analysis of zebrafish (Danio rerio) brain and spleen infected with spring viremia of carp virus (SVCV). Wang Y, et al. Fish Shellfish Immunol, 2017 Oct. PMID 28757199
    3. Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. Nakajima H, et al. PLoS One, 2011. PMID 22046393, Free PMC Article
    4. Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. Sundström G, et al. BMC Evol Biol, 2008 Sep 19. PMID 18803835, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables primary methylamine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within amine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    retina-specific copper amine oxidase
    Names
    amine oxidase, copper containing 3
    NP_001013573.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013555.3 → NP_001013573.3  retina-specific copper amine oxidase

      Status: PROVISIONAL

      Source sequence(s)
      CT583642
      UniProtKB/TrEMBL
      A0A8M1N4I9
      Related
      ENSDARP00000121793.1, ENSDART00000140117.3
      Conserved Domains (4) summary
      PRK11504
      Location:58 → 709
      tynA; tyramine oxidase; Provisional
      pfam01179
      Location:307 → 710
      Cu_amine_oxid; Copper amine oxidase, enzyme domain
      pfam02727
      Location:61 → 144
      Cu_amine_oxidN2; Copper amine oxidase, N2 domain
      pfam02728
      Location:194 → 258
      Cu_amine_oxidN3; Copper amine oxidase, N3 domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      32924186..32927605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395227.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      269492..272908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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