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    ndufaf6 NADH:ubiquinone oxidoreductase complex assembly factor 6 [ Danio rerio (zebrafish) ]

    Gene ID: 569692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndufaf6provided by ZNC
    Official Full Name
    NADH:ubiquinone oxidoreductase complex assembly factor 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100112-1
    See related
    Ensembl:ENSDARG00000053652 AllianceGenome:ZFIN:ZDB-GENE-100112-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gb:bc097249; si:ch211-233e16.1
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to act upstream of or within biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 5 and nuclear type mitochondrial complex I deficiency 17. Orthologous to human NDUFAF6 (NADH:ubiquinone oxidoreductase complex assembly factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ndufaf6 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (40487734..40508616, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (40537694..40558733, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene beta-2 adrenergic receptor Neighboring gene uncharacterized LOC137487959 Neighboring gene N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Neighboring gene tumor protein p53 inducible nuclear protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of zebrafish PLEKHF2 presents in egg/embryos as an antibacterial protein. Ren Y, et al. Fish Shellfish Immunol, 2022 Aug. PMID 35863537
    2. A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish. Sabharwal A, et al. Genes (Basel), 2022 Jul 23. PMID 35893052, Free PMC Article
    3. Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. Lam SH, et al. BMC Med Genomics, 2011 May 16. PMID 21575170, Free PMC Article
    4. FusX: A Rapid One-Step Transcription Activator-Like Effector Assembly System for Genome Science. Ma AC, et al. Hum Gene Ther, 2016 Jun. PMID 26854857, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) complex I, assembly factor 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      40487734..40508616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466778.2 → XP_021322453.2  NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1

      UniProtKB/TrEMBL
      A0A8M9P823
      Related
      ENSDARP00000070200.5, ENSDART00000075718.6

    2. XM_068214211.1 → XP_068070312.1  NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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