slc31a1 solute carrier family 31 member 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc31a1provided by ZNC
Official Full Name: solute carrier family 31 member 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040415-3
See related: Ensembl:ENSDARG00000013961 AllianceGenome:ZFIN:ZDB-GENE-040415-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ctr1; ctr-1; zgc:76839
Summary: Predicted to enable copper ion transmembrane transporter activity. Acts upstream of or within cellular response to estrogen stimulus; hypotonic salinity response; and response to copper ion. Predicted to be located in basolateral plasma membrane; late endosome membrane; and lateral plasma membrane. Is expressed in gill; gut; liver; locus coeruleus; and yolk syncytial layer. Orthologous to human SLC31A1 (solute carrier family 31 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (57328535..57354915)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (56658318..56684698)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish ctr1 or atox1 overexpression increased Cu accumulation in zebrafish liver cell line ZFL.
Title: Functional characterization of copper transporters zCtr1, zAtox1, zAtp7a and zAtp7b in zebrafish liver cell line ZFL.
Studies show that zebrafish ctr1 is an essential gene for development.
Title: Cloning, expression pattern and essentiality of the high-affinity copper transporter 1 (ctr1) gene in zebrafish.

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General gene information

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Markers

fd61g05.y1 (e-PCR)
- UniSTS:195844

NoName (e-PCR)
- UniSTS:238377

fd46a06.x1 (e-PCR)
- UniSTS:204338

Z5538 (e-PCR)
- UniSTS:64976

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables copper ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables copper ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within copper ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within copper ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within copper ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within copper ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within hypotonic salinity response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to copper ion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: high affinity copper uptake protein 1

Names: high affinity copper uptake protein; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporters), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001320405.1 → NP_001307334.1 high affinity copper uptake protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

CF996108, FP017233

UniProtKB/TrEMBL

A0A8M1P2F2, F1QKH1

Related

ENSDARP00000123985.1, ENSDART00000149646.3

Conserved Domains (1) summary

pfam04145
Location:41 → 173

Ctr; Ctr copper transporter family
NM_205717.3 → NP_991280.2 high affinity copper uptake protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

FP017233

UniProtKB/TrEMBL

A0A8M1P2F2, F1QKH1

Related

ENSDARP00000015824.8, ENSDART00000012586.9

Conserved Domains (1) summary

pfam04145
Location:41 → 173

Ctr; Ctr copper transporter family