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    g3bp2a G3BP stress granule assembly factor 2a [ Danio rerio (zebrafish) ]

    Gene ID: 556409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    g3bp2aprovided by ZNC
    Official Full Name
    G3BP stress granule assembly factor 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070112-1972
    See related
    Ensembl:ENSDARG00000014790 AllianceGenome:ZFIN:ZDB-GENE-070112-1972
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    g3bp2; fb43h08; fe25b02; wu:fb43h08; wu:fc13c01; wu:fe25b02; zgc:158370
    Summary
    Predicted to enable mRNA binding activity and molecular condensate scaffold activity. Predicted to be involved in stress granule assembly. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human G3BP2 (G3BP stress granule assembly factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See g3bp2a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (26334385..26465429)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (25751272..25771715)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4) Neighboring gene CXXC finger 4 Neighboring gene tet methylcytosine dioxygenase 2 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 38 Neighboring gene inorganic pyrophosphatase 2 Neighboring gene integrator complex subunit 12 Neighboring gene zinc finger CCHC domain-containing protein 18-like Neighboring gene USO1 vesicle transport factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Wu Y, et al. Sci Rep, 2017 Jun 22. PMID 28642470, Free PMC Article
    2. Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos. Lemeer S, et al. Mol Cell Proteomics, 2008 Nov. PMID 18550893
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular condensate scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating protein-binding protein 2
    Names
    GTPase activating protein (SH3 domain) binding protein 2
    Ras-GTPase activating protein SH3 domain-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080563.1 → NP_001074032.1  ras GTPase-activating protein-binding protein 2

      See identical proteins and their annotated locations for NP_001074032.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129213
      UniProtKB/TrEMBL
      A0A8M1NCU4, A1L1U3
      Related
      ENSDARP00000046375.7, ENSDART00000046376.9
      Conserved Domains (2) summary
      cd00780
      Location:7 → 135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cl17169
      Location:348 → 430
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      26334385..26465429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219524.1 → XP_068075625.1  ras GTPase-activating protein-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M1NCU4, A1L1U3
      Related
      ENSDARP00000157047.1, ENSDART00000180810.1
    Nucleotide Protein
    Heading Accession and Version

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