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    mknk2a MAPK interacting serine/threonine kinase 2a [ Danio rerio (zebrafish) ]

    Gene ID: 334167, updated on 9-Dec-2024

    Summary

    Official Symbol
    mknk2aprovided by ZNC
    Official Full Name
    MAPK interacting serine/threonine kinase 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6099
    See related
    Ensembl:ENSDARG00000011373 AllianceGenome:ZFIN:ZDB-GENE-030131-6099
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi34c11; zgc:55587; wu:fi34c11; wu:fi41e12
    Summary
    Predicted to enable calcium-dependent protein serine/threonine kinase activity; calcium/calmodulin-dependent protein kinase activity; and calmodulin binding activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in lens; tail bud; and yolk syncytial layer. Orthologous to human MKNK2 (MAPK interacting serine/threonine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See mknk2a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (23006792..23024957)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (23351141..23369301)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene MLLT1 super elongation complex subunit b Neighboring gene zinc finger protein 414 Neighboring gene casein kinase 1, gamma 2a Neighboring gene major facilitator superfamily domain containing 12a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    MAP kinase-interacting serine/threonine-protein kinase 2a
    Names
    MAP kinase interacting serine/threonine kinase 2a
    MAP kinase-interacting serine/threonine kinase 2
    NP_997888.1
    XP_068079197.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212723.1NP_997888.1  MAP kinase-interacting serine/threonine-protein kinase 2a

      See identical proteins and their annotated locations for NP_997888.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045391
      UniProtKB/TrEMBL
      Q7ZVV9
      Related
      ENSDARP00000008879.8, ENSDART00000027782.10
      Conserved Domains (2) summary
      smart00220
      Location:83368
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14173
      Location:81368
      STKc_Mnk2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      23006792..23024957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223096.1XP_068079197.1  MAP kinase-interacting serine/threonine-protein kinase 2a isoform X1