eml1 EMAP like 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eml1provided by ZNC
Official Full Name: EMAP like 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-156
See related: Ensembl:ENSDARG00000042840 AllianceGenome:ZFIN:ZDB-GENE-060929-156
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fj01a06; zgc:153105
Summary: Predicted to enable microtubule binding activity. Acts upstream of or within cone photoresponse recovery. Predicted to colocalize with mitotic spindle. Is expressed in anterior macula; eye; oocyte; and retinal cone cell. Human ortholog(s) of this gene implicated in subcortical band heterotopia. Orthologous to human EML1 (EMAP like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (30978932..31082010, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (30961967..31065093, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We characterize light sensitivity recovery in continuously illuminated wild-type zebrafish cones and demonstrate that sensitivity recovery does not occur in the absence of EML1.
Title: EML1 (CNG-modulin) controls light sensitivity in darkness and under continuous illumination in zebrafish retinal cone photoreceptors.

Submit: New GeneRIF Correction

General gene information

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Markers

fj80f06.y1 (e-PCR)
- UniSTS:199968

fj01a06.x1 (e-PCR)
- UniSTS:198234

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cone photoresponse recovery	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: echinoderm microtubule-associated protein-like 1

Names: CNG-modulin; echinoderm microtubule associated protein like 1; eml1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193598.1 → NP_001180527.1 echinoderm microtubule-associated protein-like 1

Status: VALIDATED

Source sequence(s)

BX546478

UniProtKB/TrEMBL

A0A8M1NV07, E7EXY5

Related

ENSDARP00000104791.2, ENSDART00000126414.4

Conserved Domains (4) summary

COG2319
Location:254 → 708

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:184 → 257

HELP; HELP motif

sd00039
Location:373 → 415

7WD40; WD40 repeat [structural motif]

cl02567
Location:264 → 569

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

30978932..31082010 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467231.2 → XP_021322906.1 echinoderm microtubule-associated protein-like 1 isoform X5

UniProtKB/TrEMBL

A0A8M9PKW5

Related

ENSDARP00000149673.1, ENSDART00000193865.1

Conserved Domains (3) summary

sd00039
Location:387 → 429

7WD40; WD40 repeat [structural motif]

pfam03451
Location:198 → 271

HELP; HELP motif

cl25539
Location:278 → 583

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_005158803.5 → XP_005158860.1 echinoderm microtubule-associated protein-like 1 isoform X6

UniProtKB/TrEMBL

A0A8M2B5R3

Conserved Domains (4) summary

COG2319
Location:263 → 717

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:193 → 266

HELP; HELP motif

sd00039
Location:382 → 424

7WD40; WD40 repeat [structural motif]

cl02567
Location:273 → 578

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_021467230.2 → XP_021322905.1 echinoderm microtubule-associated protein-like 1 isoform X4

UniProtKB/TrEMBL

A0A8M9PNX0

Conserved Domains (3) summary

sd00039
Location:391 → 433

7WD40; WD40 repeat [structural motif]

pfam03451
Location:202 → 275

HELP; HELP motif

cl25539
Location:282 → 587

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_021467228.2 → XP_021322903.1 echinoderm microtubule-associated protein-like 1 isoform X2

UniProtKB/TrEMBL

A0A8M9P921

Conserved Domains (3) summary

sd00039
Location:399 → 441

7WD40; WD40 repeat [structural motif]

pfam03451
Location:211 → 284

HELP; HELP motif

cl25539
Location:291 → 595

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_021467227.2 → XP_021322902.1 echinoderm microtubule-associated protein-like 1 isoform X1

UniProtKB/TrEMBL

A0A8M9P088

Related

ENSDARP00000137688.2, ENSDART00000172721.3

Conserved Domains (3) summary

sd00039
Location:400 → 442

7WD40; WD40 repeat [structural motif]

pfam03451
Location:211 → 284

HELP; HELP motif

cl25539
Location:291 → 596

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_005158804.4 → XP_005158861.1 echinoderm microtubule-associated protein-like 1 isoform X7

UniProtKB/TrEMBL

A0A2R8RMY7, A0A8M2B5A8

Related

ENSDARP00000148944.1, ENSDART00000185941.1

Conserved Domains (4) summary

COG2319
Location:258 → 712

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:188 → 261

HELP; HELP motif

sd00039
Location:377 → 419

7WD40; WD40 repeat [structural motif]

cl02567
Location:268 → 573

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_021467229.2 → XP_021322904.1 echinoderm microtubule-associated protein-like 1 isoform X3

UniProtKB/TrEMBL

A0A8M9PED7

Conserved Domains (3) summary

sd00039
Location:395 → 437

7WD40; WD40 repeat [structural motif]

pfam03451
Location:206 → 279

HELP; HELP motif

cl25539
Location:286 → 591

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001076583.1: Suppressed sequence

Description

NM_001076583.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from rat: Eml1 (GeneID:362783).