mstnb myostatin b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mstnbprovided by ZNC
Official Full Name: myostatin bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-165
See related: Ensembl:ENSDARG00000069133 AllianceGenome:ZFIN:ZDB-GENE-990415-165
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gdf8; mstn; mstn-1; zgc:109749
Summary: This gene encodes a member of the TGF-beta (transforming growth factor beta) family of growth and differentiation factors that negatively regulates the development and growth of skeletal muscle mass. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional peptide. Transgenic fish expressing the prodomain of the encoded protein in the skeletal muscles exhibit an increased number of myofibers without a significant difference in fiber size. Knockdown of the expression of this gene in fish induces body mass increases due to hyperplasia or hypertrophy. [provided by RefSeq, Jun 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (40939336..40943137)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (41137549..41141350)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mstnb and Inhbaa inversely control Smad2 and Smad3 transcription factor activities through alternate Activin type 2 receptors.
Title: Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair.
The results indicate that mstnb but not mstna plays a key role in zebrafish muscle growth. While each paralogue contributes to the response to bacterial insult, mstnb affects the immune system through activation of the NF-kappaB pathway, and mstna is likely to act upstream of NF-kappaB at some as yet unidentified target.
Title: Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish.
improving muscle growth in a fish species by mixing a classical strategy, such as compensatory growth, and a biotechnological approach, such as the use of recombinant proteins for inhibiting the biological actions of MSTN(Myostatin)
Title: Transient inactivation of myostatin induces muscle hypertrophy and overcompensatory growth in zebrafish via inactivation of the SMAD signaling pathway.
Fasting effect on myostatin-1 and -2 mRNA expression is strain specific.
Title: Inbred strains of zebrafish exhibit variation in growth performance and myostatin expression following fasting.
Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis
Title: Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling.
The results show that mstn-1 gene expression is more sensitive to nutrient conditions of fish than traditional indicators such as the RNA/DNA ratio.
Title: Feeding restriction alters expression of some ATP related genes more sensitively than the RNA/DNA ratio in zebrafish, Danio rerio.
the expression of myostatin during development and the effects of its knock-down on various genes such as muscle regulatory transcription factors (MRFs), muscle-specific proteins (MSP), and insulin-like growth factors (IGFs).
Title: Up-regulation of muscle-specific transcription factors during embryonic somitogenesis of zebrafish (Danio rerio) by knock-down of myostatin-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within_negative_effect cardiac muscle myoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle organ development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cardiac muscle myoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of growth	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of growth rate	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of striated muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of muscle hyperplasia	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth/differentiation factor 8

Names: myostatin-1; myostatin-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131019.5 → NP_571094.2 growth/differentiation factor 8 preproprotein

Status: REVIEWED

Source sequence(s)

BX323586

UniProtKB/Swiss-Prot

B0S643, O42222, Q7T1K5, Q8JFS0, Q8UUR8

Related

ENSDARP00000091159.1, ENSDART00000100386.2

Conserved Domains (2) summary

smart00204
Location:280 → 374

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:38 → 252

TGFb_propeptide; TGF-beta propeptide