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    hnrnpl heterogeneous nuclear ribonucleoprotein L [ Danio rerio (zebrafish) ]

    Gene ID: 394074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hnrnplprovided by ZNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Lprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-710
    See related
    Ensembl:ENSDARG00000035324 AllianceGenome:ZFIN:ZDB-GENE-040426-710
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hnrpl; zgc:55429
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within mRNA processing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Is expressed in central nervous system and neural keel. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hnrnpl in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (36900157..36911903)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (36300004..36311750)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member 2a Neighboring gene serine and arginine rich splicing factor 7a Neighboring gene kaptin (actin binding protein) Neighboring gene cone-rod homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. hnRNP L is essential for myogenic differentiation and modulates myotonic dystrophy pathologies. Alexander MS, et al. Muscle Nerve, 2021 Jun. PMID 33651408, Free PMC Article
    2. On the tubulin polymerization promoting proteins of zebrafish. Orosz F. Biochem Biophys Res Commun, 2015 Feb 13. PMID 25576359
    3. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Zhang Y, et al. Cell Rep, 2017 Jan 10. PMID 28076796, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55429

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201099.1 → NP_957393.1  heterogeneous nuclear ribonucleoprotein L

      See identical proteins and their annotated locations for NP_957393.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045336
      UniProtKB/TrEMBL
      A0A2R8QMT5, F6PE75, Q7ZW09
      Related
      ENSDARP00000051183.4, ENSDART00000051184.5
      Conserved Domains (6) summary
      cd12704
      Location:446 → 529
      RRM4_hnRNPL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
      cd12780
      Location:39 → 118
      RRM1_hnRNPL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
      cd12785
      Location:128 → 227
      RRM2_hnRNPL; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)
      pfam02084
      Location:265 → 322
      Bindin; Bindin
      TIGR01649
      Location:39 → 534
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:330 → 403
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      36900157..36911903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476043.2 → XP_021331718.1  heterogeneous nuclear ribonucleoprotein L isoform X1

      UniProtKB/TrEMBL
      A0A8M9PX80
      Conserved Domains (1) summary
      TIGR01649
      Location:39 → 522
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394595.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      141172..156962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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