ptmaa prothymosin alpha a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptmaaprovided by ZNC
Official Full Name: prothymosin alpha aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7647
See related: Ensembl:ENSDARG00000021113 AllianceGenome:ZFIN:ZDB-GENE-030131-7647
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ptma; cb515; fk58d04; sb:cb515; zgc:85633; wu:fb77b12; wu:fk58d04; zgc:158634
Summary: Predicted to enable histone binding activity. Predicted to be involved in negative regulation of apoptotic process and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including Leydig cell; corpuscles of Stannius; digestive system; nervous system; and pleuroperitoneal region. Orthologous to human PTMA (prothymosin alpha). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (29791197..29795029)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (29800636..29804468)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that prothymosin alpha (PTMA) transcripts are expressed in the testis, and localize in meiotic and post-meiotic germ cells, namely spermatocytes and spermatids.
Title: Prothymosin alpha expression and localization during the spermatogenesis of Danio rerio.
Overexpression of Ptmaa in zebrafish epidermal cells promotes proliferation and attenuates UVB-induced apoptosis but does not cause skin cancer.
Title: Transgenic expression of prothymosin alpha on zebrafish epidermal cells promotes proliferation and attenuates UVB-induced apoptosis.
Data show that prothymosin alpha, a single copy gene found in all organisms investigated so far, is duplicated in zebrafish, and suggest that their function in cell proliferation and differentiation is more complex in fishes than in mammals.
Title: Differential expression of duplicated genes for prothymosin alpha during zebrafish development.

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General gene information

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Markers

fk58d04.x1 (e-PCR)
- UniSTS:201243

fb77b12.x1 (e-PCR)
- UniSTS:191344

fb77b12.x1 (e-PCR)
- UniSTS:191345

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prothymosin alpha-A

NP_919357.2

EC 3.1.3.66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.