nepro nucleolus and neural progenitor protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: neproprovided by ZNC
Official Full Name: nucleolus and neural progenitor proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5651
See related: Ensembl:ENSDARG00000043566 AllianceGenome:ZFIN:ZDB-GENE-030131-5651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi11c01; wu:fi11c01; zgc:112065; si:dkey-22a1.3
Summary: Predicted to be involved in negative regulation of neuron differentiation and positive regulation of Notch signaling pathway. Predicted to be located in nucleolus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in anauxetic dysplasia 3. Orthologous to human NEPRO (nucleolus and neural progenitor protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (27381498..27391908, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (27570752..27581162, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nucleolus and neural progenitor protein

Names: protein nepro homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017650.2 → NP_001017650.2 nucleolus and neural progenitor protein

Status: VALIDATED

Source sequence(s)

CR392351, EH549216, EH570337

UniProtKB/Swiss-Prot

Q567G6, Q5RI41

UniProtKB/TrEMBL

A0A2R8Q988, A0A8M1N532

Related

ENSDARP00000115468.1, ENSDART00000135221.2

Conserved Domains (1) summary

pfam14780
Location:6 → 195

DUF4477; Domain of unknown function (DUF4477)