dag1 dystroglycan 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dag1provided by ZNC
Official Full Name: dystroglycan 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-021223-1
See related: Ensembl:ENSDARG00000016153 AllianceGenome:ZFIN:ZDB-GENE-021223-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dag; wu:fb83d06; wu:fi25f06; wu:fi37b08; zgc:109786
Summary: Enables laminin binding activity. Acts upstream of or within several processes, including T-tubule organization; skeletal muscle organ development; and somatic muscle development. Located in sarcolemma. Is expressed in several structures, including mesoderm; nervous system; pronephros; trunk; and trunk musculature. Used to study muscular dystrophy-dystroglycanopathy type B1. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia; inclusion body myositis; and muscular dystrophy (multiple). Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (33132024..33194805)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (33177382..33240229)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fkrp plays an early and essential role in muscle, myotendinous junction, and neuromuscular junction development. The data also indicate that, at least in the zebrafish model, FKRP-associated dystroglycanopathy does not exactly phenocopy dystroglycan deficiency.
Title: NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy.
Patchytail fish contain a point mutation (c.1700T>A) in dag1, resulting in a missense change leading to skeletal muscle defects, brain abnormalities and ocular defects in posterior as well as anterior chambers.
Title: The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies.
genetic evidence that neuromuscular synapse formation can occur in the absence of MuSK and that the combinatorial function of UnpFL/MuSK and dystroglycan generates diverse patterns of vertebrate neuromuscular innervation
Title: Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation.
Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos.
Title: Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos.

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General gene information

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Markers

fi37b08.x1 (e-PCR)
- UniSTS:197401

G39561 (e-PCR)
- UniSTS:30746

fb83d06.x1 (e-PCR)
- UniSTS:203489

fi25f06.x1 (e-PCR)
- UniSTS:197111

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables laminin binding	IBA Inferred from Biological aspect of Ancestor more info
enables laminin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-tubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in morphogenesis of an epithelium	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle attachment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within muscle attachment	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within receptor clustering	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dystroglycan complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dystrophin-associated glycoprotein complex	IEA Inferred from Electronic Annotation more info
part_of dystrophin-associated glycoprotein complex	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dystroglycan 1

Names: dystrophin-associated glycoprote; dystrophin-associated glycoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173274.1 → NP_775381.1 dystroglycan 1 precursor

See identical proteins and their annotated locations for NP_775381.1

Status: PROVISIONAL

Source sequence(s)

AF483476

UniProtKB/TrEMBL

Q8JHU7

Related

ENSDARP00000020759.6, ENSDART00000004504.8

Conserved Domains (4) summary

cd11303
Location:79 → 171

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

cd11305
Location:192 → 314

alpha_DG_C; C-terminal domain of alpha dystroglycan

smart00736
Location:476 → 570

CADG; Dystroglycan-type cadherin-like domains

pfam05454
Location:580 → 866

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

33132024..33194805

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009296487.4 → XP_009294762.1 dystroglycan 1 isoform X1

See identical proteins and their annotated locations for XP_009294762.1

UniProtKB/TrEMBL

A0A8M3AUX6, F1QMH7

Conserved Domains (4) summary

cd11303
Location:79 → 171

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

cd11305
Location:192 → 314

alpha_DG_C; C-terminal domain of alpha dystroglycan

smart00736
Location:476 → 570

CADG; Dystroglycan-type cadherin-like domains

pfam05454
Location:580 → 866

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
XM_005170544.5 → XP_005170601.1 dystroglycan 1 isoform X1

See identical proteins and their annotated locations for XP_005170601.1

UniProtKB/TrEMBL

A0A8M3AUX6, F1QMH7

Related

ENSDARP00000106371.1, ENSDART00000126885.3

Conserved Domains (4) summary

cd11303
Location:79 → 171

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

cd11305
Location:192 → 314

alpha_DG_C; C-terminal domain of alpha dystroglycan

smart00736
Location:476 → 570

CADG; Dystroglycan-type cadherin-like domains

pfam05454
Location:580 → 866

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)