mcfd2 multiple coagulation factor deficiency 2, ER cargo receptor complex subunit [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mcfd2provided by ZNC
Official Full Name: multiple coagulation factor deficiency 2, ER cargo receptor complex subunitprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-8
See related: Ensembl:ENSDARG00000039757 AllianceGenome:ZFIN:ZDB-GENE-041010-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hm:zeh1186; wu:fc23b10; wu:fd50d08; zgc:103713; zgc:109915
Summary: Predicted to enable calcium ion binding activity. Orthologous to human MCFD2 (multiple coagulation factor deficiency 2, ER cargo receptor complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (8683638..8692870, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (8353058..8360831, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc23b10.x1 (e-PCR)
- UniSTS:187826

fd50d08.x1 (e-PCR)
- UniSTS:195580

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: multiple coagulation factor deficiency protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005939.2 → NP_001005939.1 multiple coagulation factor deficiency protein 2 precursor

See identical proteins and their annotated locations for NP_001005939.1

Status: VALIDATED

Source sequence(s)

BX004962

UniProtKB/TrEMBL

A0A8N7XJE6, F1R786, F6P951, Q5XJ39

Related

ENSDARP00000058106.6, ENSDART00000058107.7

Conserved Domains (2) summary

pfam13499
Location:85 → 151

EF-hand_7; EF-hand domain pair

cl08302
Location:85 → 150

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...