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    col15a1b collagen, type XV, alpha 1b [ Danio rerio (zebrafish) ]

    Gene ID: 558137, updated on 9-Dec-2024

    Summary

    Official Symbol
    col15a1bprovided by ZNC
    Official Full Name
    collagen, type XV, alpha 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-689
    See related
    Ensembl:ENSDARG00000061848 AllianceGenome:ZFIN:ZDB-GENE-070912-689
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb491; sb:cb491; wu:fb50f05; wu:fc22d09; si:dkeyp-93c5.1
    Summary
    Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within eye development and regulation of motor neuron axon guidance. Predicted to be part of collagen trimer. Predicted to be active in basement membrane and extracellular space. Is expressed in several structures, including aortic arch; digestive system; nervous system; neural plate; and neural tube. Orthologous to human COL15A1 (collagen type XV alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See col15a1b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (23937068..24013234, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (24281303..24357596, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487820 Neighboring gene VOPP1 WW domain binding protein a Neighboring gene transforming growth factor, beta receptor 1 a Neighboring gene solute carrier family 12 member 7a Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 2a Neighboring gene uncharacterized LOC137487821

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    General protein information

    Preferred Names
    collagen, type XV, alpha 1b
    Names
    col15a1
    collagen XV alpha 1 chain
    collagen type XV-B alpha 1 chain
    mz98
    novel collagen protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172370.2NP_001165841.2  collagen, type XV, alpha 1b precursor

      See identical proteins and their annotated locations for NP_001165841.2

      Status: PROVISIONAL

      Source sequence(s)
      FN432724
      UniProtKB/TrEMBL
      D3GN36
      Related
      ENSDARP00000122740.2, ENSDART00000137065.4
      Conserved Domains (3) summary
      pfam01391
      Location:697743
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:9921161
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      cl22861
      Location:43222
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      23937068..24013234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358519.3XP_017214008.1  collagen, type XV, alpha 1b isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z1E7
      Related
      ENSDARP00000083076.6, ENSDART00000088643.6
    2. XM_005171235.5XP_005171292.1  collagen, type XV, alpha 1b isoform X4

      UniProtKB/TrEMBL
      A0A8M2BIM9
      Conserved Domains (3) summary
      pfam01391
      Location:490544
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:10821251
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      cl22861
      Location:43222
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    3. XM_009298514.4XP_009296789.1  collagen, type XV, alpha 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M3B7P8
      Conserved Domains (3) summary
      pfam01391
      Location:546600
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:11261295
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      cl22861
      Location:99278
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    4. XM_005171234.5XP_005171291.1  collagen, type XV, alpha 1b isoform X3

      UniProtKB/TrEMBL
      A0A8M2BII4
      Conserved Domains (3) summary
      pfam01391
      Location:546600
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:11241293
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      cl22861
      Location:99278
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    5. XM_009298513.4XP_009296788.1  collagen, type XV, alpha 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M3APP4
      Conserved Domains (3) summary
      pfam01391
      Location:546600
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:11381307
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      cl22861
      Location:99278
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...