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    gart phosphoribosylglycinamide formyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 58141, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gartprovided by ZNC
    Official Full Name
    phosphoribosylglycinamide formyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000616-14
    See related
    AllianceGenome:ZFIN:ZDB-GENE-000616-14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb33g04
    Summary
    Predicted to enable phosphoribosylamine-glycine ligase activity and phosphoribosylformylglycinamidine cyclo-ligase activity. Acts upstream of or within camera-type eye development; chordate embryonic development; and pigmentation. Predicted to be active in cytosol. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; nervous system; and yolk syncytial layer. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See gart in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (973067..1005061, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (139908..188514, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495378 Neighboring gene N-6 adenine-specific DNA methyltransferase 1 Neighboring gene uncharacterized LOC100332351 Neighboring gene uncharacterized LOC101886071

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod. Alejevski F, et al. Open Biol, 2021 Aug. PMID 34375549, Free PMC Article
    2. Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development. Ng A, et al. Development, 2009 Aug. PMID 19570845, Free PMC Article
    3. Integrative analysis of circadian transcriptome and metabolic network reveals the role of de novo purine synthesis in circadian control of cell cycle. Li Y, et al. PLoS Comput Biol, 2015 Feb. PMID 25714999, Free PMC Article
    4. Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Lewis VM, et al. Proc Natl Acad Sci U S A, 2019 Jun 11. PMID 31138706, Free PMC Article
    5. Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. Zheng W, et al. PLoS One, 2014. PMID 24633177, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two recessive zebrafish mutations that affect de novo purine synthesis, gart and paics, were analyzed.
      Title: Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylglycinamide formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    trifunctional purine biosynthetic protein adenosine-3
    NP_571692.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131617.1 → NP_571692.1  trifunctional purine biosynthetic protein adenosine-3

      See identical proteins and their annotated locations for NP_571692.1

      Status: PROVISIONAL

      Source sequence(s)
      AF257743
      UniProtKB/TrEMBL
      Q9I9E6
      Conserved Domains (7) summary
      cd02196
      Location:469 → 767
      PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
      cd08645
      Location:814 → 996
      FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
      PRK00885
      Location:4 → 427
      PRK00885; phosphoribosylamine--glycine ligase; Provisional
      PRK05385
      Location:436 → 764
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
      pfam01071
      Location:105 → 298
      GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
      pfam02843
      Location:334 → 425
      GARS_C; Phosphoribosylglycinamide synthetase, C domain
      pfam02844
      Location:4 → 104
      GARS_N; Phosphoribosylglycinamide synthetase, N domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      973067..1005061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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