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    slc37a4a solute carrier family 37 member 4a [ Danio rerio (zebrafish) ]

    Gene ID: 406465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc37a4aprovided by ZNC
    Official Full Name
    solute carrier family 37 member 4aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2230
    See related
    Ensembl:ENSDARG00000038106 AllianceGenome:ZFIN:ZDB-GENE-040426-2230
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc25d06; slc37a4; zgc:77098; wu:fc25d06
    Summary
    Predicted to enable glucose 6-phosphate:phosphate antiporter activity. Acts upstream of or within response to steroid hormone. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in intestinal bulb; liver; ovary; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II; glycogen storage disease Ib; and glycogen storage disease Ic. Orthologous to human SLC37A4 (solute carrier family 37 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slc37a4a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (9297380..9315084)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (9318536..9339014)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene calmodulin 3a (phosphorylase kinase, delta) Neighboring gene si:ch211-261a10.5 Neighboring gene trafficking protein particle complex subunit 4 Neighboring gene sarcoglycan, gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fine selection of up-regulated genes during ovulation by in vivo induction of oocyte maturation and ovulation in zebrafish. Klangnurak W, et al. Zoological Lett, 2017. PMID 28265462, Free PMC Article
    2. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glucose 6-phosphate:phosphate antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose-6-phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-6-phosphate exchanger SLC37A4a
    Names
    glycerol-6-phosphate transporter
    solute carrier family 37 (glucose-6-phosphate transporter), member 4
    solute carrier family 37 (glucose-6-phosphate transporter), member 4a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214738.1 → NP_999903.1  glucose-6-phosphate exchanger SLC37A4a

      See identical proteins and their annotated locations for NP_999903.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066719
      UniProtKB/TrEMBL
      A0A8M3AH42, F1R0A9, Q6NY67
      Related
      ENSDARP00000055553.5, ENSDART00000055554.6
      Conserved Domains (2) summary
      cd06174
      Location:14 → 415
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00881
      Location:18 → 397
      2A0104; phosphoglycerate transporter family protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      9297380..9315084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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