zgc:171446 zgc:171446 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: zgc:171446provided by ZNC
Official Full Name: zgc:171446provided by ZNC
Primary source: ZFIN:ZDB-GENE-080205-1
See related: Ensembl:ENSDARG00000116005 AllianceGenome:ZFIN:ZDB-GENE-080205-1
Gene type: protein coding
RefSeq status: PREDICTED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. Orthologous to human PZP (PZP alpha-2-macroglobulin like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 3

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (3402225..3413669, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (3619972..3631416, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uncharacterized protein LOC100136837

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114556.1 → NP_001108028.1 uncharacterized protein LOC100136837

See identical proteins and their annotated locations for NP_001108028.1

Status: PREDICTED

Source sequence(s)

BC154440

UniProtKB/TrEMBL

A0A8M9Q2V0, A8WFS6

Related

ENSDARP00000100695.2, ENSDART00000115331.4

Conserved Domains (7) summary

COG2373
Location:147 → 1074

YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]

cd02897
Location:965 → 1240

A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...

pfam00207
Location:747 → 835

A2M; Alpha-2-macroglobulin family

pfam01835
Location:146 → 237

A2M_N; MG2 domain

pfam07677
Location:1359 → 1448

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1017 → 1240

A2M_comp; A-macroglobulin complement component

pfam07703
Location:481 → 625

A2M_N_2; Alpha-2-macroglobulin family N-terminal region