slc39a7 solute carrier family 39 member 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc39a7provided by ZNC
Official Full Name: solute carrier family 39 member 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-991110-20
See related: Ensembl:ENSDARG00000104451 AllianceGenome:ZFIN:ZDB-GENE-991110-20
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ke4; HKE4; ZIP7; id:ibd5081; wu:fc28c09
Summary: Predicted to enable zinc ion transmembrane transporter activity. Acts upstream of or within intracellular zinc ion homeostasis. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Is expressed in brain; eye; gill; muscle; and optic cup. Human ortholog(s) of this gene implicated in agammaglobulinemia 9. Orthologous to human SLC39A7 (solute carrier family 39 member 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (18903559..18915935)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (19330589..19342982)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slc39a7/zip7 plays a critical role in development and zinc homeostasis in zebrafish.
Title: Slc39a7/zip7 plays a critical role in development and zinc homeostasis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fb37g10.x1 (e-PCR)
- UniSTS:203159

fc28c09.x1 (e-PCR)
- UniSTS:187897

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular zinc ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within metal ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of ferroptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in skin epidermis development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zinc ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within zinc ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within zinc ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc transporter Slc39a7

Names: histidine-rich membrane protein Ke4; solute carrier family 39 (zinc transporter), member 7; zrt-, Irt-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130931.3 → NP_571006.3 zinc transporter Slc39a7 precursor

Status: VALIDATED

Source sequence(s)

EH509633, EH611820, FP067442

UniProtKB/Swiss-Prot

A3KPZ7, Q9PUB8

UniProtKB/TrEMBL

Q6DGU8

Related

ENSDARP00000130247.1, ENSDART00000166562.2

Conserved Domains (1) summary

pfam02535
Location:122 → 441

Zip; ZIP Zinc transporter