llgl2 LLGL scribble cell polarity complex component 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: llgl2provided by ZNC
Official Full Name: LLGL scribble cell polarity complex component 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9877
See related: Ensembl:ENSDARG00000023920 AllianceGenome:ZFIN:ZDB-GENE-030131-9877
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lgl2; cb521; llglh2; sb:cb521; zgc:55895; wu:fc06g08; wu:fl37c09
Summary: Predicted to enable GTPase activator activity and myosin II binding activity. Acts upstream of or within with a positive effect on cell projection assembly. Acts upstream of or within several processes, including Kupffer's vesicle development; hemidesmosome assembly; and photoreceptor cell morphogenesis. Predicted to be located in cytoskeleton. Predicted to be active in cortical actin cytoskeleton and plasma membrane. Is expressed in several structures, including EVL; Kupffer's vesicle; digestive system; mesoderm; and sensory system. Orthologous to human LLGL2 (LLGL scribble cell polarity complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (33738361..33788952, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (33637378..33687969, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

aPKC regulates apical localization of Lgl1 and Lgl2 to restrict elongation of microridges in developing zebrafish epidermis.
Title: aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis.
New roles and interactions for Lgl2 that are crucial for both lumenogenesis and ciliogenesis and indicate that these processes are genetically separable in zebrafish.
Title: Lethal giant larvae 2 regulates development of the ciliated organ Kupffer's vesicle.
Lgl2 and E-cadherin act antagonistically to control the localisation of integrin alpha 6 during the formation of hemidesmosomes in the developing epidermis
Title: Lgl2 and E-cadherin act antagonistically to regulate hemidesmosome formation during epidermal development in zebrafish.
lgl2 is necessary for hemidesmosome formation and maintenance of the tissue integrity in the developing basal epidermis
Title: Zebrafish penner/lethal giant larvae 2 functions in hemidesmosome formation, maintenance of cellular morphology and growth regulation in the developing basal epidermis.

Submit: New GeneRIF Correction

General gene information

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Markers

fd24d03.y1 (e-PCR)
- UniSTS:195328

fc06g08.x1 (e-PCR)
- UniSTS:203734

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables myosin II binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Kupffer's vesicle development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell projection assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within_positive_effect cell projection assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemidesmosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoreceptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of epidermis development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skin epidermis development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: LLGL scribble cell polarity complex component 2

Names: lethal giant larvae homolog 2; lethal(2) giant larvae protein homolog 2; pen; penner; protein penner

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212582.1 → NP_997747.1 LLGL scribble cell polarity complex component 2

See identical proteins and their annotated locations for NP_997747.1

Status: PROVISIONAL

Source sequence(s)

BC052919

UniProtKB/Swiss-Prot

Q7SZE3

UniProtKB/TrEMBL

B7ZVM2

Related

ENSDARP00000035593.7, ENSDART00000034550.9

Conserved Domains (3) summary

sd00039
Location:36 → 72

7WD40; WD40 repeat [structural motif]

pfam08366
Location:273 → 369

LLGL; LLGL2

cl29593
Location:29 → 253

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

33738361..33788952 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480170.2 → XP_021335845.1 LLGL scribble cell polarity complex component 2 isoform X1

UniProtKB/TrEMBL

A0A8M9QMN2

Related

ENSDARP00000148623.1, ENSDART00000193258.1

Conserved Domains (3) summary

sd00039
Location:36 → 72

7WD40; WD40 repeat [structural motif]

pfam08366
Location:273 → 369

LLGL; LLGL2

cl25539
Location:29 → 253

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...