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    chaf1b chromatin assembly factor 1, subunit B [ Danio rerio (zebrafish) ]

    Gene ID: 406285, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chaf1bprovided by ZNC
    Official Full Name
    chromatin assembly factor 1, subunit Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1947
    See related
    Ensembl:ENSDARG00000056473 AllianceGenome:ZFIN:ZDB-GENE-040426-1947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fe36g06; zgc:56096; wu:fd07c09; wu:fe36g06; wu:fv38g09
    Summary
    Acts upstream of or within embryonic organ development; mitotic cell cycle; and retina development in camera-type eye. Predicted to be part of CAF-1 complex. Predicted to be active in nucleus. Is expressed in head; immature eye; optic tectum; pectoral fin; and trunk. Orthologous to human CHAF1B (chromatin assembly factor 1 subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See chaf1b in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (30543142..30555760, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (30732396..30745014, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:dkey-229b18.3 Neighboring gene E3 SUMO-protein ligase ZBED1 Neighboring gene MORC family CW-type zinc finger 3a Neighboring gene COMM domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The phenotype of the good effort mutant zebrafish is retinal degeneration by cell death and is linked to the chromosome assembly factor 1b gene. Bailey TJ, et al. Adv Exp Med Biol, 2014. PMID 24664741
    2. Mutation of zebrafish caf-1b results in S phase arrest, defective differentiation, and p53-mediated apoptosis during organogenesis. Fischer S, et al. Cell Cycle, 2007 Dec 1. PMID 18156805
    3. Smarca5-mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Ding Y, et al. Blood, 2021 Jan 14. PMID 32756943, Free PMC Article
    4. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication-dependent chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryonic organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CAF-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chromatin assembly factor 1 subunit B
    Names
    gef

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328129.1 → NP_001315058.1  chromatin assembly factor 1 subunit B

      Status: VALIDATED

      Source sequence(s)
      BX571809, CT737124
      UniProtKB/TrEMBL
      A0A8M1P3K0, E7EYR2
      Related
      ENSDARP00000073678.4, ENSDART00000079222.5
      Conserved Domains (4) summary
      COG2319
      Location:10 → 386
      WD40; WD40 repeat [General function prediction only]
      pfam15512
      Location:388 → 596
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal
      sd00039
      Location:70 → 128
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:11 → 375
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      30543142..30555760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_213012.1: Suppressed sequence

      Description
      NM_213012.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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