U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rbm22 RNA binding motif protein 22 [ Danio rerio (zebrafish) ]

    Gene ID: 406495, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    rbm22provided by ZNC
    Official Full Name
    RNA binding motif protein 22provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2298
    See related
    Ensembl:ENSDARG00000010238 AllianceGenome:ZFIN:ZDB-GENE-040426-2298
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb37a01; fc62e03; fe05c04; zgc:77910; wu:fb37a01; wu:fc62e03; wu:fe05c04
    Summary
    Predicted to enable U6 snRNA binding activity and pre-mRNA binding activity. Acts upstream of or within chordate embryonic development. Located in nucleus. Orthologous to human RBM22 (RNA binding motif protein 22). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rbm22 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (33211303..33229917, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (33178136..33196750, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene myozenin-2 Neighboring gene ADP ribosylation factor like GTPase 3, like 1 Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1b Neighboring gene uncharacterized LOC137488834 Neighboring gene uncharacterized LOC137488835

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos. He F, et al. Genet Mol Res, 2009 Dec 8. PMID 20013661
    2. Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22. Montaville P, et al. Biochim Biophys Acta, 2006 Nov. PMID 17045351
    3. Evolutionary plasticity of segmentation clock networks. Krol AJ, et al. Development, 2011 Jul. PMID 21652651, Free PMC Article
    4. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Ozbudak EM, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160088, Free PMC Article
    5. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U6 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U6 snRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA cis splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 1 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    pre-mRNA-splicing factor RBM22

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213214.1 → NP_998379.1  pre-mRNA-splicing factor RBM22

      See identical proteins and their annotated locations for NP_998379.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065892
      UniProtKB/Swiss-Prot
      Q6NZZ9
      Related
      ENSDARP00000004055.7, ENSDART00000003983.10
      Conserved Domains (3) summary
      smart00356
      Location:159 → 185
      ZnF_C3H1; zinc finger
      COG0724
      Location:186 → 307
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12224
      Location:231 → 304
      RRM_RBM22; RNA recognition motif (RRM) found in Pre-mRNA-splicing factor RBM22 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      33211303..33229917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZZ9.1 GenPept UniProtKB/Swiss-Prot:Q6NZZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.