ubap1 ubiquitin associated protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ubap1provided by ZNC
Official Full Name: ubiquitin associated protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-950
See related: Ensembl:ENSDARG00000058746 AllianceGenome:ZFIN:ZDB-GENE-040426-950
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: UBAP-1; zgc:56228
Summary: Predicted to enable ubiquitin binding activity. Acts upstream of or within axon extension. Predicted to be located in cytosol and endosome. Predicted to be part of ESCRT I complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 80. Orthologous to human UBAP1 (ubiquitin associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (11865957..11881908)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (11773329..11789280)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi30e09.y1 (e-PCR)
- UniSTS:197246

fc31g12.x1 (e-PCR)
- UniSTS:193523

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT I complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328344.1 → NP_001315273.1 ubiquitin-associated protein 1

Status: VALIDATED

Source sequence(s)

CU694487, EH488960

UniProtKB/Swiss-Prot

F6P6X0, Q7ZV44

Related

ENSDARP00000076116.5, ENSDART00000081676.6

Conserved Domains (5) summary

PHA03247
Location:120 → 332

PHA03247; large tegument protein UL36; Provisional

cd14315
Location:339 → 381

UBA1_UBAP1; UBA1 domain found in vertebrate ubiquitin-associated protein 1 (UBAP-1)

cd14316
Location:411 → 447

UBA2_UBAP1_like; UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins

TIGR00601
Location:273 → 380

rad23; UV excision repair protein Rad23

pfam10240
Location:12 → 61

DUF2464; Multivesicular body subunit 12

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

11865957..11881908

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_200214.1: Suppressed sequence

Description

NM_200214.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.