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    tacc3 transforming, acidic coiled-coil containing protein 3 [ Danio rerio (zebrafish) ]

    Gene ID: 321283, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tacc3provided by ZNC
    Official Full Name
    transforming, acidic coiled-coil containing protein 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-327
    See related
    Ensembl:ENSDARG00000005454 AllianceGenome:ZFIN:ZDB-GENE-050522-327
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb500; sb:cb500; wu:fd20f10; zgc:111850
    Summary
    Predicted to be involved in cerebral cortex development; microtubule cytoskeleton organization; and nuclear migration. Predicted to act upstream of or within mitotic spindle organization. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; pectoral fin musculature; pharynx; proliferative region; and retina. Orthologous to human TACC3 (transforming acidic coiled-coil containing protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tacc3 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (35880574..35892243, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (35754740..35766411, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Neighboring gene mitogen-activated protein kinase kinase kinase 4 Neighboring gene potassium channel, subfamily K, member 1b Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid a Neighboring gene MYCL proto-oncogene, bHLH transcription factor a Neighboring gene uncharacterized LOC103912028

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling. Sun X, et al. Theranostics, 2020. PMID 32641982, Free PMC Article
    2. Slc20a1b is essential for hematopoietic stem/progenitor cell expansion in zebrafish. Chen J, et al. Sci China Life Sci, 2021 Dec. PMID 33751369
    3. RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Yang Y, et al. Mol Cell, 2019 Sep 19. PMID 31399345
    4. Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. Still IH, et al. BMC Evol Biol, 2004 Jun 18. PMID 15207008, Free PMC Article
    5. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC192381

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transforming acidic coiled-coil-containing protein 3
    Names
    transforming acidic coiled coil 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212581.1 → NP_997746.1  transforming acidic coiled-coil-containing protein 3

      See identical proteins and their annotated locations for NP_997746.1

      Status: PROVISIONAL

      Source sequence(s)
      AY170618
      UniProtKB/TrEMBL
      Q6Y8G7
      Related
      ENSDARP00000022481.7, ENSDART00000002750.9
      Conserved Domains (2) summary
      pfam05010
      Location:737 → 934
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl23750
      Location:742 → 900
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      35880574..35892243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156975.4 → XP_005157032.1  transforming acidic coiled-coil-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3X9, B8A574
      Related
      ENSDARP00000141834.1, ENSDART00000162399.2
      Conserved Domains (2) summary
      pfam05010
      Location:737 → 934
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl23750
      Location:742 → 900
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    Nucleotide Protein Strain
    Heading Accession and Version

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