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    dhrs9 dehydrogenase/reductase (SDR family) member 9 [ Danio rerio (zebrafish) ]

    Gene ID: 322529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhrs9provided by ZNC
    Official Full Name
    dehydrogenase/reductase (SDR family) member 9provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1249
    See related
    Ensembl:ENSDARG00000019260 AllianceGenome:ZFIN:ZDB-GENE-030131-1249
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    RDHA; rdh1l; zgc:73286; wu:fb64b07
    Summary
    Enables all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within several processes, including digestive system development; embryonic organ morphogenesis; and retinoid metabolic process. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including digestive system; hypoblast; immature eye; macrophage; and pectoral fin bud. Orthologous to human DHRS9 (dehydrogenase/reductase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dhrs9 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (48706039..48736182, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (49008554..49038697, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 2a Neighboring gene uncharacterized LOC137496504 Neighboring gene retinol dehydrogenase 1 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 11a Neighboring gene SPC25 component of NDC80 kinetochore complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative genomic and phylogenetic analysis of short-chain dehydrogenases/reductases with dual retinol/sterol substrate specificity. Belyaeva OV, et al. Genomics, 2006 Dec. PMID 16860536
    2. Functional aspects of 17beta-hydroxysteroid dehydrogenase 1 determined by comparison to a closely related retinol dehydrogenase. Mindnich R, et al. J Steroid Biochem Mol Biol, 2007 May. PMID 17467981
    3. Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases. Nadauld LD, et al. J Biol Chem, 2006 Dec 8. PMID 17028196
    4. The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli. Nadauld LD, et al. J Biol Chem, 2005 Aug 26. PMID 15967793
    5. Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. Nadauld LD, et al. J Biol Chem, 2004 Dec 3. PMID 15358764

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APC controls the production of RA in the gut by regulating the expression of the retinol dehydrogenase, rdh1l
      Title: The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli.
    2. zRDHA and zRDHB show strong expression within the gut of developing zebrafish embryos
      Title: Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation.
    3. A role for G143 in zebrafish 17beta-HSD 1 and M146 and M147 in the two zebrafish paralogs prRDH 1 and prRDH 2, respectively, in substrate specificity.
      Title: Functional aspects of 17beta-hydroxysteroid dehydrogenase 1 determined by comparison to a closely related retinol dehydrogenase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pectoral fin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retinol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 9
    Names
    retinol dehydrogenase 1, like
    NP_955903.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199609.1 → NP_955903.1  dehydrogenase/reductase SDR family member 9

      See identical proteins and their annotated locations for NP_955903.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059614
      UniProtKB/TrEMBL
      Q6PBR3
      Related
      ENSDARP00000027139.6, ENSDART00000022074.8
      Conserved Domains (2) summary
      pfam00106
      Location:30 → 211
      adh_short; short chain dehydrogenase
      cl21454
      Location:30 → 307
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      48706039..48736182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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