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    impdh2 IMP (inosine 5'-monophosphate) dehydrogenase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 317745, updated on 27-Dec-2024

    Summary

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    Official Symbol
    impdh2provided by ZNC
    Official Full Name
    IMP (inosine 5'-monophosphate) dehydrogenase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030114-5
    See related
    Ensembl:ENSDARG00000006900 AllianceGenome:ZFIN:ZDB-GENE-030114-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb635; IMPD 2; IMPDH 2; wu:fb64g02; wu:fc43f09
    Summary
    Predicted to enable IMP dehydrogenase activity. Acts upstream of or within circadian rhythm. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; immature eye; mesoderm; muscle; and nervous system. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See impdh2 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (26059595..26079140)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (26040432..26060000)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene xeroderma pigmentosum, complementation group C Neighboring gene ariadne homolog 2 (Drosophila) Neighboring gene microRNA 462 Neighboring gene microRNA 731

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. IMPDH forms the cytoophidium in zebrafish. Keppeke GD, et al. Dev Biol, 2021 Oct. PMID 34048735
    2. Mycophenolic Acid-Induced Developmental Defects in Zebrafish Embryos. Jiang LL, et al. Int J Toxicol, 2016 Nov. PMID 27694306
    3. Identification of amacrine subtypes that express the atypical cadherin celsr3. Lewis AA, et al. Exp Eye Res, 2015 Jan. PMID 25479044, Free PMC Article
    4. A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells. Cleghorn WM, et al. J Biol Chem, 2022 Jan. PMID 34813793, Free PMC Article
    5. Integrative analysis of circadian transcriptome and metabolic network reveals the role of de novo purine synthesis in circadian control of cell cycle. Li Y, et al. PLoS Comput Biol, 2015 Feb. PMID 25714999, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IMPDH forms the cytoophidium in zebrafish.
      Title: IMPDH forms the cytoophidium in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables IMP dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IMP dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IMP dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GTP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inosine-5'-monophosphate dehydrogenase 2
    Names
    IMP (inosine monophosphate) dehydrogenase 2
    NP_958872.1
    XP_005167045.1
    XP_021333858.1
    XP_021333859.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201464.1 → NP_958872.1  inosine-5'-monophosphate dehydrogenase 2

      See identical proteins and their annotated locations for NP_958872.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046905
      UniProtKB/TrEMBL
      Q7ZYW9
      Related
      ENSDARP00000024354.8, ENSDART00000009178.9
      Conserved Domains (3) summary
      cd00381
      Location:29 → 480
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
      cd04602
      Location:115 → 230
      CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
      PTZ00314
      Location:16 → 510
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      26059595..26079140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478183.2 → XP_021333858.1  inosine-5'-monophosphate dehydrogenase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q3A2
      Conserved Domains (1) summary
      PTZ00314
      Location:16 → 554
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    2. XM_005166988.5 → XP_005167045.1  inosine-5'-monophosphate dehydrogenase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BEA6
      Conserved Domains (3) summary
      cd00381
      Location:29 → 500
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
      cd04602
      Location:115 → 250
      CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
      PTZ00314
      Location:16 → 530
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    3. XM_021478184.2 → XP_021333859.1  inosine-5'-monophosphate dehydrogenase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q9I4
      Conserved Domains (1) summary
      PTZ00314
      Location:16 → 534
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0UXP9.1 GenPept UniProtKB/Swiss-Prot:B0UXP9

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