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    snrnp70 small nuclear ribonucleoprotein 70 (U1) [ Danio rerio (zebrafish) ]

    Gene ID: 445398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snrnp70provided by ZNC
    Official Full Name
    small nuclear ribonucleoprotein 70 (U1)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040825-2
    See related
    Ensembl:ENSDARG00000077126 AllianceGenome:ZFIN:ZDB-GENE-040825-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    snrp70; wu:fc20b04; zgc:136450
    Summary
    Predicted to enable U1 snRNA binding activity and mRNA binding activity. Acts upstream of or within hematopoietic stem cell differentiation. Predicted to be located in nucleus. Predicted to be part of U1 snRNP and U2-type prespliceosome. Is expressed in central nervous system; hematopoietic stem cell; and motor neurons. Human ortholog(s) of this gene implicated in disease of mental health and systemic lupus erythematosus. Orthologous to human SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See snrnp70 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (31925054..31933774)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (31793347..31802057)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box helicase 42 Neighboring gene STE20 related adaptor alpha Neighboring gene ring finger protein 113A Neighboring gene uncharacterized LOC110439178 Neighboring gene lin-7 homolog B (C. elegans) Neighboring gene zgc:193811

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish. Yu Y, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25735748, Free PMC Article
    2. Cytoplasmic pool of U1 spliceosome protein SNRNP70 shapes the axonal transcriptome and regulates motor connectivity. Nikolaou N, et al. Curr Biol, 2022 Dec 5. PMID 36384140
    3. A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Burns CE, et al. Blood, 2009 Jun 4. PMID 19332767, Free PMC Article
    4. cpsf1 is required for definitive HSC survival in zebrafish. Bolli N, et al. Blood, 2011 Apr 14. PMID 21330472, Free PMC Article
    5. Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Thomas-Jinu S, et al. Neuron, 2017 Apr 19. PMID 28392072, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136450

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U1 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U1 small nuclear ribonucleoprotein 70 kDa
    Names
    U1 small nuclear ribonucleoprotein polypeptide A
    U1 small ribonucleoprotein 70kd
    small nuclear ribonucleoprotein 70kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003875.2 → NP_001003875.1  U1 small nuclear ribonucleoprotein 70 kDa

      See identical proteins and their annotated locations for NP_001003875.1

      Status: VALIDATED

      Source sequence(s)
      BX324157
      UniProtKB/TrEMBL
      A0A8M1N1Q9, Q6DRE8
      Related
      ENSDARP00000055278.3, ENSDART00000055279.5
      Conserved Domains (3) summary
      COG0724
      Location:98 → 182
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12236
      Location:102 → 187
      RRM_snRNP70; RNA recognition motif in U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and similar proteins
      pfam12220
      Location:2 → 57
      U1snRNP70_N; U1 small nuclear ribonucleoprotein of 70kDa MW N terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      31925054..31933774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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