uqcrc1 ubiquinol-cytochrome c reductase core protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uqcrc1provided by ZNC
Official Full Name: ubiquinol-cytochrome c reductase core protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1792
See related: Ensembl:ENSDARG00000052304 AllianceGenome:ZFIN:ZDB-GENE-040426-1792
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73404; zgc:85750
Summary: Predicted to enable metal ion binding activity. Predicted to be active in mitochondrion. Is expressed in several structures, including cerebellum; epidermis; gut; inner ear; and liver and biliary system. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human UQCRC1 (ubiquinol-cytochrome c reductase core protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (22337164..22351941)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (20276942..20291719)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome b-c1 complex subunit 1, mitochondrial

Names: ubiquinol-cytochrome c reductase core I protein; ubiquinol-cytochrome c reductase core protein I

NP_957114.1

EC 7.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200820.1 → NP_957114.1 cytochrome b-c1 complex subunit 1, mitochondrial

See identical proteins and their annotated locations for NP_957114.1

Status: PROVISIONAL

Source sequence(s)

BC059705

UniProtKB/TrEMBL

Q6PBH6

Related

ENSDARP00000148999.1, ENSDART00000138930.2

Conserved Domains (3) summary

COG0612
Location:39 → 463

PqqL; Predicted Zn-dependent peptidase [General function prediction only]

pfam00675
Location:52 → 199

Peptidase_M16; Insulinase (Peptidase family M16)

pfam05193
Location:204 → 389

Peptidase_M16_C; Peptidase M16 inactive domain