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    agmo alkylglycerol monooxygenase [ Danio rerio (zebrafish) ]

    Gene ID: 405819, updated on 9-Dec-2024

    Summary

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    Official Symbol
    agmoprovided by ZNC
    Official Full Name
    alkylglycerol monooxygenaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2207
    See related
    Ensembl:ENSDARG00000025595 AllianceGenome:ZFIN:ZDB-GENE-040426-2207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tmem195; zgc:77121
    Summary
    Predicted to enable glyceryl-ether monooxygenase activity and iron ion binding activity. Predicted to be involved in ether lipid metabolic process and membrane lipid metabolic process. Predicted to act upstream of or within lipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human AGMO (alkylglycerol monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See agmo in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34334721..34418525, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (34476752..34560556, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene ETS variant transcription factor 1 Neighboring gene uncharacterized LOC137487770 Neighboring gene diacylglycerol kinase, beta Neighboring gene mesenchyme homeobox 2a Neighboring gene CDP-L-ribitol pyrophosphorylase A Neighboring gene sclerostin domain containing 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. El-Sammak H, et al. Circ Res, 2022 Apr. PMID 35264012, Free PMC Article
    2. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77121

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glyceryl-ether monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyceryl-ether monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyceryl-ether monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ether lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alkylglycerol monooxygenase
    Names
    transmembrane protein 195
    NP_998048.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212883.2 → NP_998048.2  alkylglycerol monooxygenase

      Status: VALIDATED

      Source sequence(s)
      BX470068, CK028737, CN511695, EH513834, EH597521
      UniProtKB/Swiss-Prot
      Q6NYE4
      UniProtKB/TrEMBL
      A0A8M1PI86
      Related
      ENSDARP00000122798.1, ENSDART00000147582.3
      Conserved Domains (2) summary
      COG3000
      Location:91 → 252
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:118 → 248
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      34334721..34418525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NYE4.1 GenPept UniProtKB/Swiss-Prot:Q6NYE4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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