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    cd81a CD81 molecule a [ Danio rerio (zebrafish) ]

    Gene ID: 58031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cd81aprovided by ZNC
    Official Full Name
    CD81 molecule aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000831-5
    See related
    Ensembl:ENSDARG00000036080 AllianceGenome:ZFIN:ZDB-GENE-000831-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cd81; wu:fc07d07; hm:zehn0171
    Summary
    Predicted to enable lipid binding activity. Predicted to act upstream of or within adaptive immune response. Predicted to be located in basolateral plasma membrane and lateral plasma membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency 6. Orthologous to human CD81 (CD81 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cd81a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (32983440..33023339, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (32712290..32752189, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene anoctamin 9b Neighboring gene plakophilin 3b Neighboring gene potassium voltage-gated channel, Shaw-related subfamily, member 1a Neighboring gene uncharacterized LOC137496179 Neighboring gene tryptophan hydroxylase 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A temporal single cell transcriptome atlas of zebrafish anterior segment development. Vöcking O, et al. Sci Rep, 2023 Apr 6. PMID 37024546, Free PMC Article
    2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CD81 molecule a
    Names
    CD81 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131518.2 → NP_571593.2  CD81 molecule a

      See identical proteins and their annotated locations for NP_571593.2

      Status: PROVISIONAL

      Source sequence(s)
      BC057419
      UniProtKB/TrEMBL
      A0A8M1PC71, Q6PFU1
      Related
      ENSDARP00000052382.5, ENSDART00000052383.7
      Conserved Domains (2) summary
      cd03151
      Location:115 → 202
      CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:11 → 230
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      32983440..33023339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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