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    hnrnpk heterogeneous nuclear ribonucleoprotein K [ Danio rerio (zebrafish) ]

    Gene ID: 406267, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hnrnpkprovided by ZNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Kprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1926
    See related
    Ensembl:ENSDARG00000018914 AllianceGenome:ZFIN:ZDB-GENE-040426-1926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hnrpk; zgc:66162; wu:fb37h02; wu:fi34c04
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; gut; otic vesicle; pectoral fin; and ventral mesoderm. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hnrnpk in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (49745668..49766241, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (49756899..49777472, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene G kinase anchoring protein 1 Neighboring gene Q-nucleotide N-glycosylase 1 Neighboring gene RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) Neighboring gene neurotrophic tyrosine kinase, receptor, type 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Genetic Model to Study Increased Hexosamine Biosynthetic Flux. Hugo SE, et al. Endocrinology, 2017 Aug 1. PMID 28582574, Free PMC Article
    2. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827
    3. Evolution after Whole-Genome Duplication: Teleost MicroRNAs. Desvignes T, et al. Mol Biol Evol, 2021 Jul 29. PMID 33871629, Free PMC Article
    4. Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Boswell M, et al. Sci Rep, 2020 Feb 24. PMID 32094353, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein K

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212994.2 → NP_998159.2  heterogeneous nuclear ribonucleoprotein K

      See identical proteins and their annotated locations for NP_998159.2

      Status: VALIDATED

      Source sequence(s)
      BI704444, CR376792, CU682767, DR719329, EB912144
      UniProtKB/TrEMBL
      A0A8M3B580, F1QWB4
      Related
      ENSDARP00000088691.3, ENSDART00000097919.5
      Conserved Domains (3) summary
      cd00105
      Location:355 → 418
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:122 → 183
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam08067
      Location:9 → 43
      ROKNT; ROKNT (NUC014) domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      49745668..49766241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167319.5 → XP_005167376.1  heterogeneous nuclear ribonucleoprotein K isoform X3

      UniProtKB/TrEMBL
      A0A2R8Q139, A0A8M2BEM9
      Related
      ENSDARP00000146195.1, ENSDART00000189142.1
      Conserved Domains (3) summary
      cd00105
      Location:343 → 406
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:122 → 183
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam08067
      Location:9 → 43
      ROKNT; ROKNT (NUC014) domain

    2. XM_068222911.1 → XP_068079012.1  heterogeneous nuclear ribonucleoprotein K isoform X2

    3. XM_009304280.4 → XP_009302555.1  heterogeneous nuclear ribonucleoprotein K isoform X1

      See identical proteins and their annotated locations for XP_009302555.1

      UniProtKB/TrEMBL
      A0A8M3B580, F1QWB4
      Conserved Domains (3) summary
      cd00105
      Location:355 → 418
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:122 → 183
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam08067
      Location:9 → 43
      ROKNT; ROKNT (NUC014) domain
    Nucleotide Protein
    Heading Accession and Version

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