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    plekhf2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 393214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plekhf2provided by ZNC
    Official Full Name
    pleckstrin homology domain containing, family F (with FYVE domain) member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-884
    See related
    Ensembl:ENSDARG00000021141 AllianceGenome:ZFIN:ZDB-GENE-040426-884
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56073
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endosome organization and endosome to lysosome transport. Predicted to act upstream of or within protein transport. Predicted to be located in early endosome membrane and endoplasmic reticulum. Predicted to be active in early endosome. Is expressed in brain; caudal fin; eye; spleen; and testis. Orthologous to human PLEKHF2 (pleckstrin homology and FYVE domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See plekhf2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (40425873..40459104, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (40473929..40529916, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487958 Neighboring gene T-cell differentiation antigen CD6 Neighboring gene beta-2 adrenergic receptor Neighboring gene uncharacterized LOC137487959

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of zebrafish PLEKHF2 presents in egg/embryos as an antibacterial protein. Ren Y, et al. Fish Shellfish Immunol, 2022 Aug. PMID 35863537
    2. An in silico mining for simple sequence repeats from expressed sequence tags of zebrafish, medaka, Fundulus, and Xiphophorus. Ju Z, et al. In Silico Biol, 2005. PMID 16268789
    3. Reconstruction of a 450-My-old ancestral vertebrate protokaryotype. Kohn M, et al. Trends Genet, 2006 Apr. PMID 16517001
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC56073

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family F member 2
    Names
    PH domain-containing family F member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200244.1 → NP_956538.1  pleckstrin homology domain-containing family F member 2

      See identical proteins and their annotated locations for NP_956538.1

      Status: PROVISIONAL

      Source sequence(s)
      BC047820
      UniProtKB/Swiss-Prot
      Q7ZUV1
      UniProtKB/TrEMBL
      B2GRF1
      Related
      ENSDARP00000038743.4, ENSDART00000032389.5
      Conserved Domains (3) summary
      cd01218
      Location:7 → 129
      PH_Phafin2-like; Phafin2 (also called EAPF, FLJ13187, ZFYVE18 or PLEKHF2) Pleckstrin Homology (PH) domain
      cd15755
      Location:148 → 211
      FYVE_PKHF2; FYVE domain found in protein containing both PH and FYVE domains 2 (phafin-2) and similar proteins
      pfam00169
      Location:39 → 131
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      40425873..40459104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZUV1.1 GenPept UniProtKB/Swiss-Prot:Q7ZUV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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