hnrpkl heterogeneous nuclear ribonucleoprotein K, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hnrpklprovided by ZNC
Official Full Name: heterogeneous nuclear ribonucleoprotein K, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1923
See related: Ensembl:ENSDARG00000007034 AllianceGenome:ZFIN:ZDB-GENE-040426-1923
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56206; wu:fc19f05; wu:fc48a08; wu:fc84b09; wu:fd16g02
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (55603855..55625243, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (54933638..54955050, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fc48a08 (e-PCR)
- UniSTS:189220

fd10f01.y1 (e-PCR)
- UniSTS:195116

fc19f05.x1 (e-PCR)
- UniSTS:203851

fc19f05.x1 (e-PCR)
- UniSTS:187785

fc84b09.x1 (e-PCR)
- UniSTS:188328

G46927 (e-PCR)
- UniSTS:107722

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein K, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212991.3 → NP_998156.3 heterogeneous nuclear ribonucleoprotein K, like

Status: VALIDATED

Source sequence(s)

CT708088, CU468920, EB831522

UniProtKB/TrEMBL

A0A8M1PG37, B8JLJ8

Related

ENSDARP00000116598.1, ENSDART00000133156.3

Conserved Domains (3) summary

cd00105
Location:357 → 420

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:123 → 187

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

pfam08067
Location:10 → 44

ROKNT; ROKNT (NUC014) domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

55603855..55625243 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009301843.4 → XP_009300118.1 heterogeneous nuclear ribonucleoprotein K, like isoform X1

UniProtKB/TrEMBL

A0A8M3ASQ8, F6PB84

Related

ENSDARP00000008648.10, ENSDART00000005671.10

Conserved Domains (3) summary

cd00105
Location:346 → 409

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:123 → 187

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

pfam08067
Location:10 → 44

ROKNT; ROKNT (NUC014) domain