timp2a TIMP metallopeptidase inhibitor 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: timp2aprovided by ZNC
Official Full Name: TIMP metallopeptidase inhibitor 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030612-1
See related: Ensembl:ENSDARG00000061226 AllianceGenome:ZFIN:ZDB-GENE-030612-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: timp2; fa96h09; wu:fa96h09; zgc:136726; etID32613.12
Summary: Predicted to enable metalloendopeptidase inhibitor activity. Predicted to be involved in negative regulation of membrane protein ectodomain proteolysis; response to cytokine; and response to hormone. Predicted to act upstream of or within negative regulation of peptidase activity. Located in extracellular space. Is expressed in several structures, including brain; heart; liver; post-vent region; and trunk. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (33990947..34035310, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (33889964..33934327, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

membrane-type 1 metalloproteinase, gelatinase A , and tissue inhibitor 2 of metalloproteinases mRNA transcripts were expressed in the blastema
Title: Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2.
To further study the function of TIMP-2 in development, we utilized zebrafish as an experimental model system
Title: The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hormone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metalloproteinase inhibitor 2a

Names: tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinase 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182874.1 → NP_878294.1 metalloproteinase inhibitor 2a precursor

See identical proteins and their annotated locations for NP_878294.1

Status: PROVISIONAL

Source sequence(s)

AY324194

UniProtKB/TrEMBL

Q7SZM6

Related

ENSDARP00000081499.4, ENSDART00000087065.6

Conserved Domains (1) summary

cd03585
Location:26 → 209

NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...