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    sptbn2 spectrin, beta, non-erythrocytic 2 [ Danio rerio (zebrafish) ]

    Gene ID: 558044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sptbn2provided by ZNC
    Official Full Name
    spectrin, beta, non-erythrocytic 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-787
    See related
    Ensembl:ENSDARG00000053956 AllianceGenome:ZFIN:ZDB-GENE-030131-787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb48h06; wu:fb48h06; si:dkey-99p10.2
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of spectrin. Predicted to be active in several cellular components, including cell junction; cortical actin cytoskeleton; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 14 and spinocerebellar ataxia type 5. Orthologous to human SPTBN2 (spectrin beta, non-erythrocytic 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sptbn2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (37618889..37711851)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37018635..37111694)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene latent transforming growth factor beta binding protein 3 Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene CDC42 effector protein (Rho GTPase binding) 2 Neighboring gene double PHD fingers 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pla2g6 Deficiency in Zebrafish Leads to Dopaminergic Cell Death, Axonal Degeneration, Increased β-Synuclein Expression, and Defects in Brain Functions and Pathways. Sánchez E, et al. Mol Neurobiol, 2018 Aug. PMID 29344929
    2. Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Farnsworth DR, et al. Exp Eye Res, 2021 May. PMID 33705730, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spectrin IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spectrin family protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099989.1 → NP_001093459.1  spectrin family protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX276181, CT025939
      UniProtKB/TrEMBL
      A0A8M1NF56, A0A8M2BCL2, F1QXB0
      Related
      ENSDARP00000088494.3, ENSDART00000097723.4
      Conserved Domains (6) summary
      smart00150
      Location:465 → 563
      SPEC; Spectrin repeats
      cd00014
      Location:213 → 316
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:997 → 1201
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2230 → 2333
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:2230 → 2333
      PH; PH domain
      pfam00435
      Location:341 → 451
      Spectrin; Spectrin repeat

    2. NM_001423118.1 → NP_001410047.1  spectrin family protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX276181, CT025939, FP102018
      UniProtKB/TrEMBL
      A0A8M2BCL2, A0A8M2BCP3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      37618889..37711851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221211.1 → XP_068077312.1  spectrin family protein isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCL2

    2. XM_068221213.1 → XP_068077314.1  spectrin family protein isoform X3

      UniProtKB/TrEMBL
      A0A8M2BCL2, A0A8M9PK72
      Related
      ENSDARP00000124243.1, ENSDART00000149151.3

    3. XM_068221212.1 → XP_068077313.1  spectrin family protein isoform X2

      UniProtKB/TrEMBL
      A0A8M2BCL2

    4. XM_068221214.1 → XP_068077315.1  spectrin family protein isoform X4

      UniProtKB/TrEMBL
      A0A8M2BCL2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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