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    atp2b1a ATPase plasma membrane Ca2+ transporting 1a [ Danio rerio (zebrafish) ]

    Gene ID: 378746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atp2b1aprovided by ZNC
    Official Full Name
    ATPase plasma membrane Ca2+ transporting 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030925-29
    See related
    Ensembl:ENSDARG00000012684 AllianceGenome:ZFIN:ZDB-GENE-030925-29
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pmca1; pmca1a; sb:cb801; wu:fe47b06; wu:fi41d01; si:dkey-18o7.1
    Summary
    Predicted to enable P-type calcium transporter activity. Acts upstream of or within several processes, including bone mineralization; inner ear development; and sensory perception of sound. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle and plasma membrane. Is expressed in several structures, including digestive system; hematopoietic system; midbrain neural tube; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See atp2b1a in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (16076719..16124431, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (16077964..16125664, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103910441 Neighboring gene uncharacterized LOC100535588 Neighboring gene uncharacterized LOC101885185 Neighboring gene uncharacterized LOC137491536 Neighboring gene uncharacterized LOC103910439 Neighboring gene si:dkeyp-38g8.5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Plasma membrane calcium ATPase required for semicircular canal formation and otolith growth in the zebrafish inner ear. Cruz S, et al. J Exp Biol, 2009 Mar. PMID 19218514
    2. atp2b1a regulates Ca(2+) export during differentiation and regeneration of mechanosensory hair cells in zebrafish. Go W, et al. Cell Calcium, 2010 Nov. PMID 21084119
    3. Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia. Langenbacher AD, et al. Front Physiol, 2020. PMID 33424641, Free PMC Article
    4. Plasma membrane Ca(2+) ATPase Atp2b1a regulates bone mineralization in zebrafish. Go W, et al. Bone, 2013 May. PMID 23353107
    5. BDNF-TrkB axis regulates migration of the lateral line primordium and modulates the maintenance of mechanoreceptor progenitors. Gasanov EV, et al. PLoS One, 2015. PMID 25751404, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activity of Atp2b1a is required to facilitate calcification of the developing pharyngeal teeth by the dental epithelium.
      Title: Plasma membrane Ca(2+) ATPase Atp2b1a regulates bone mineralization in zebrafish.
    2. Atp2b1a functions during progenitor cell proliferation and hair cell differentiation
      Title: atp2b1a regulates Ca(2+) export during differentiation and regeneration of mechanosensory hair cells in zebrafish.
    3. Atp2b1a plays an important role for normal development of the auditory and vestibular system as well as calcium transport in the inner ear of zebrafish.
      Title: Plasma membrane calcium ATPase required for semicircular canal formation and otolith growth in the zebrafish inner ear.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inner ear receptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within otolith development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within posterior lateral line neuromast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tooth mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    plasma membrane calcium-transporting ATPase 1
    Names
    ATPase, Ca++ transporting, plasma membrane 1a
    plasma membrane calcium ATPase 1
    NP_001038222.1
    XP_009298531.1
    XP_021330639.1
    XP_021330640.1
    XP_021330641.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044757.1 → NP_001038222.1  plasma membrane calcium-transporting ATPase 1

      See identical proteins and their annotated locations for NP_001038222.1

      Status: PROVISIONAL

      Source sequence(s)
      BX649423
      UniProtKB/TrEMBL
      B7ZVL0, F6PDY7
      Related
      ENSDARP00000072130.5, ENSDART00000077664.7
      Conserved Domains (7) summary
      TIGR01517
      Location:10 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:191 → 464
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:880 → 1058
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:49 → 116
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1105 → 1154
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:687 → 806
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:525 → 611
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      16076719..16124431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474964.2 → XP_021330639.1  plasma membrane calcium-transporting ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q0B2
      Related
      ENSDARP00000109980.2, ENSDART00000128079.3
      Conserved Domains (2) summary
      pfam12424
      Location:1105 → 1182
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:10 → 1064
      E1-E2_ATPase; E1-E2 ATPase

    2. XM_021474965.2 → XP_021330640.1  plasma membrane calcium-transporting ATPase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QB28
      Conserved Domains (2) summary
      pfam12424
      Location:1105 → 1156
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:10 → 1064
      E1-E2_ATPase; E1-E2 ATPase

    3. XM_009300256.4 → XP_009298531.1  plasma membrane calcium-transporting ATPase 1 isoform X1

      See identical proteins and their annotated locations for XP_009298531.1

      UniProtKB/TrEMBL
      A0A8M9Q0B2
      Conserved Domains (2) summary
      pfam12424
      Location:1105 → 1182
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:10 → 1064
      E1-E2_ATPase; E1-E2 ATPase

    4. XM_021474966.2 → XP_021330641.1  plasma membrane calcium-transporting ATPase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q5T9
      Conserved Domains (2) summary
      pfam12424
      Location:1105 → 1191
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:10 → 1064
      E1-E2_ATPase; E1-E2 ATPase
    Nucleotide Protein Strain
    Heading Accession and Version

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