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    mcm2 minichromosome maintenance complex component 2 [ Danio rerio (zebrafish) ]

    Gene ID: 192338, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mcm2provided by ZNC
    Official Full Name
    minichromosome maintenance complex component 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020419-24
    See related
    Ensembl:ENSDARG00000102798 AllianceGenome:ZFIN:ZDB-GENE-020419-24
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb737; chunp6905
    Summary
    Enables chromatin binding activity. Acts upstream of or within regulation of cilium assembly; retina development in camera-type eye; and thymus development. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in several structures, including hindbrain neural rod; midbrain neural rod; optic vesicle; paraxial mesoderm; and thymus. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mcm2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (5633811..5654783, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (5603965..5624937, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene zgc:171566 Neighboring gene podocalyxin-like 2 Neighboring gene coiled-coil domain containing 51 Neighboring gene deoxyribonuclease 1 like 4, tandem duplicate 1 Neighboring gene translation machinery associated 7 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors. Idilli AI, et al. Cancers (Basel), 2020 Apr 22. PMID 32331249, Free PMC Article
    2. Transgenic strategies to generate heterogeneous hepatic cancer models in zebrafish. Fei F, et al. J Mol Cell Biol, 2019 Dec 23. PMID 31370058, Free PMC Article
    3. Aryl hydrocarbon receptor activation produces heart-specific transcriptional and toxic responses in developing zebrafish. Carney SA, et al. Mol Pharmacol, 2006 Aug. PMID 16714409
    4. Evolutionary diversification of MCM3 genes in Xenopus laevis and Danio rerio. Shinya M, et al. Cell Cycle, 2014. PMID 25485507, Free PMC Article
    5. Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. Davuluri G, et al. PLoS Genet, 2008 Oct. PMID 18974873, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the foxn1-mcm2 axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish
      Title: Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    contributes_to 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thymus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM2
    Names
    MCM2 minichromosome maintenance deficient 2, mitotin
    NP_775364.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173257.2 → NP_775364.2  DNA replication licensing factor MCM2

      Status: VALIDATED

      Source sequence(s)
      CU467843, EH588242
      UniProtKB/TrEMBL
      A0A0R4IF65, A0A8M1PE13
      Related
      ENSDARP00000133012.1, ENSDART00000159629.3
      Conserved Domains (4) summary
      smart00350
      Location:279 → 788
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:57 → 170
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:186 → 298
      MCM_N; MCM N-terminal domain
      cl21455
      Location:506 → 645
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      5633811..5654783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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