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    psmf1 proteasome inhibitor subunit 1 [ Danio rerio (zebrafish) ]

    Gene ID: 436820, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psmf1provided by ZNC
    Official Full Name
    proteasome inhibitor subunit 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-282
    See related
    Ensembl:ENSDARG00000022652 AllianceGenome:ZFIN:ZDB-GENE-040718-282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92785
    Summary
    Predicted to enable endopeptidase inhibitor activity and proteasome binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of proteasome complex. Orthologous to human PSMF1 (proteasome inhibitor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See psmf1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (51796296..51811173, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (51796297..51811174, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 74B Neighboring gene bladder cancer associated protein Neighboring gene R-spondin 4 Neighboring gene angiopoietin 4 Neighboring gene uncharacterized LOC137496026

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Xiao A, et al. Nucleic Acids Res, 2013 Aug. PMID 23748566, Free PMC Article
    2. RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. Yang D, et al. BMC Genomics, 2012 Jul 17. PMID 22805612, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables proteasome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proteasome inhibitor PI31 subunit
    Names
    proteasome (prosome, macropain) inhibitor subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002547.2 → NP_001002547.2  proteasome inhibitor PI31 subunit

      Status: VALIDATED

      Source sequence(s)
      BX001037, CD604800, EH484771
      UniProtKB/TrEMBL
      A0A0R4II16, A0A8M1N0P9
      Related
      ENSDARP00000133267.1, ENSDART00000161048.3
      Conserved Domains (2) summary
      pfam08577
      Location:186 → 249
      PI31_Prot_C; PI31 proteasome regulator
      pfam11566
      Location:11 → 139
      PI31_Prot_N; PI31 proteasome regulator N-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      51796296..51811173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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