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    ldb3a LIM domain binding 3a [ Danio rerio (zebrafish) ]

    Gene ID: 794339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ldb3aprovided by ZNC
    Official Full Name
    LIM domain binding 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040121-6
    See related
    Ensembl:ENSDARG00000056322 AllianceGenome:ZFIN:ZDB-GENE-040121-6
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ZASP; ldb3; cypher; zehn1639; hm:zehn1639
    Summary
    Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Acts upstream of or within several processes, including locomotory behavior; skeletal muscle tissue development; and somitogenesis. Predicted to be part of filamentous actin. Predicted to be active in Z disc; adherens junction; and stress fiber. Is expressed in several structures, including adaxial cell; intestine; musculature system; pericardial region; and sensory system. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1C; distal myopathy; and myofibrillar myopathy 4. Orthologous to human LDB3 (LIM domain binding 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ldb3a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (22476793..22550416)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (22350040..22422243)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 54a Neighboring gene opsin 4a (melanopsin) Neighboring gene bone morphogenetic protein receptor, type IAa Neighboring gene multimerin 2a Neighboring gene synuclein, gamma a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapamycin attenuates pathological hypertrophy caused by an absence of trabecular formation. Fleming ND, et al. Sci Rep, 2018 Jun 5. PMID 29872120, Free PMC Article
    2. Zebrafish cypher is important for somite formation and heart development. van der Meer DL, et al. Dev Biol, 2006 Nov 15. PMID 16982050
    3. Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. Wu Q, et al. FASEB J, 2015 Dec. PMID 26310270, Free PMC Article
    4. Characterization of the Enigma family in zebrafish. Ott EB, et al. Dev Dyn, 2007 Nov. PMID 17937393
    5. Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration. Xiao C, et al. NPJ Regen Med, 2023 Apr 7. PMID 37029137, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56098

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LIM domain-binding protein 3a
    Names
    LIM-domain binding factor 3, like
    LIM-domain binding factor 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430876.1 → NP_001417805.1  LIM domain-binding protein 3a isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT573135

    2. NM_201505.2 → NP_958913.2  LIM domain-binding protein 3a isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT573135
      UniProtKB/TrEMBL
      Q7ZVD3
      Related
      ENSDARP00000073201.4, ENSDART00000078740.6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      22476793..22550416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068212948.1 → XP_068069049.1  LIM domain-binding protein 3a isoform X1

      Related
      ENSDARP00000073220.3, ENSDART00000078759.4

    2. XM_068212947.1 → XP_068069048.1  LIM domain-binding protein 3a isoform X1

    3. XM_068212952.1 → XP_068069053.1  LIM domain-binding protein 3a isoform X3

    4. XM_068212955.1 → XP_068069056.1  LIM domain-binding protein 3a isoform X5

      UniProtKB/TrEMBL
      Q7ZVD3
      Related
      ENSDARP00000116588.1, ENSDART00000137220.3

    5. XM_068212957.1 → XP_068069058.1  LIM domain-binding protein 3a isoform X6

      UniProtKB/TrEMBL
      Q7ZVD3
      Related
      ENSDARP00000119395.1, ENSDART00000133065.3

    6. XM_068212946.1 → XP_068069047.1  LIM domain-binding protein 3a isoform X1

    7. XM_068212945.1 → XP_068069046.1  LIM domain-binding protein 3a isoform X1

      Related
      ENSDARP00000115285.1, ENSDART00000131870.3

    8. XM_068212949.1 → XP_068069050.1  LIM domain-binding protein 3a isoform X2

      Related
      ENSDARP00000073218.3, ENSDART00000078757.5

    9. XM_068212950.1 → XP_068069051.1  LIM domain-binding protein 3a isoform X3

      Related
      ENSDARP00000109131.2, ENSDART00000130424.4

    10. XM_068212953.1 → XP_068069054.1  LIM domain-binding protein 3a isoform X4

      Related
      ENSDARP00000073208.4, ENSDART00000078747.7

    11. XM_068212954.1 → XP_068069055.1  LIM domain-binding protein 3a isoform X5

      UniProtKB/TrEMBL
      Q7ZVD3
      Related
      ENSDARP00000157437.1, ENSDART00000192972.1

    12. XM_021480673.2 → XP_021336348.2  LIM domain-binding protein 3a isoform X6

      UniProtKB/TrEMBL
      Q7ZVD3
      Related
      ENSDARP00000150455.1, ENSDART00000188182.1

    13. XM_068212956.1 → XP_068069057.1  LIM domain-binding protein 3a isoform X6

      UniProtKB/TrEMBL
      Q7ZVD3
      Related
      ENSDARP00000044718.5, ENSDART00000044719.7

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394883.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      365273..445930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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