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    ap1m2 adaptor related protein complex 1 subunit mu 2 [ Danio rerio (zebrafish) ]

    Gene ID: 403021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ap1m2provided by ZNC
    Official Full Name
    adaptor related protein complex 1 subunit mu 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-20
    See related
    Ensembl:ENSDARG00000096454 AllianceGenome:ZFIN:ZDB-GENE-041114-20
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Ap1m1; zgc:103537
    Summary
    Predicted to enable clathrin adaptor activity. Acts upstream of or within several processes, including digestive tract development; kidney development; and post-Golgi vesicle-mediated transport. Predicted to be part of clathrin adaptor complex. Predicted to be active in clathrin-coated vesicle. Is expressed in several structures, including digestive system; eye; heart; intestinal bulb primordium; and pleuroperitoneal region. Orthologous to human AP1M2 (adaptor related protein complex 1 subunit mu 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ap1m2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (112694..119859)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (94586..103748)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene transcription activator BRG1 Neighboring gene low density lipoprotein receptor b Neighboring gene si:zfos-323e3.4 Neighboring gene cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of the AP-1 μ1A and μ1B adaptins in zebrafish (Danio rerio). Zizioli D, et al. Dev Dyn, 2010 Sep. PMID 20652956
    2. Analysis of three μ1-AP1 subunits during zebrafish development. Gariano G, et al. Dev Dyn, 2014 Feb. PMID 24123392
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103537

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within brain development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within digestive tract development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AP-1 complex subunit mu-2
    Names
    adaptor-related protein complex 1 mu 1 subunit
    adaptor-related protein complex 1, mu 2 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205714.1 → NP_991277.1  AP-1 complex subunit mu-2

      See identical proteins and their annotated locations for NP_991277.1

      Status: PROVISIONAL

      Source sequence(s)
      AY394943
      UniProtKB/TrEMBL
      A0A8M3B038, F1R3L9, Q6TLG2
      Related
      ENSDARP00000037980.7, ENSDART00000034505.9
      Conserved Domains (1) summary
      cd09259
      Location:154 → 421
      AP-1_Mu1B_Cterm; C-terminal domain of medium Mu1B subunit in epithelial cell-specific clathrin-associated adaptor protein (AP) complex AP-1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      112694..119859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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