sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sdhbprovided by ZNC
Official Full Name: succinate dehydrogenase complex, subunit B, iron sulfur (Ip)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8005
See related: Ensembl:ENSDARG00000075768 AllianceGenome:ZFIN:ZDB-GENE-030131-8005
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Ip; fj46d06; wu:fj46d06
Summary: Predicted to enable iron-sulfur cluster binding activity; succinate dehydrogenase (quinone) activity; and ubiquinone binding activity. Acts upstream of or within mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Predicted to be active in mitochondrial membrane. Is expressed in several structures, including alar plate midbrain region; brain; eye; pronephric duct; and segmental plate. Used to study paraganglioma. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (11383..16123)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (62681..67421)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterisation of an Adult Zebrafish Model for SDHB-Associated Phaeochromocytomas and Paragangliomas.
Title: Characterisation of an Adult Zebrafish Model for SDHB-Associated Phaeochromocytomas and Paragangliomas.

Submit: New GeneRIF Correction

General gene information

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Markers

G39335 (e-PCR)
- UniSTS:8713

G46500 (e-PCR)
- UniSTS:107302

fa10c11.r1 (e-PCR)
- UniSTS:189578

fj46d06.x1 (e-PCR)
- UniSTS:199398

G44916 (e-PCR)
- UniSTS:105718

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 2 iron, 2 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables 3 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 3 iron, 4 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 4 iron, 4 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquinone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial electron transport, succinate to ubiquinone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in respiratory electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex II (succinate dehydrogenase)	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Names: Iron-sulfur subunit of complex II; malate dehydrogenase [quinone] iron-sulfur subunit

NP_001092210.1

EC 1.3.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098740.1 → NP_001092210.1 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor

See identical proteins and their annotated locations for NP_001092210.1

Status: PROVISIONAL

Source sequence(s)

BC142799

UniProtKB/Swiss-Prot

A5PL98

Related

ENSDARP00000062263.5, ENSDART00000062264.8

Conserved Domains (3) summary

PRK05950
Location:40 → 271

sdhB; succinate dehydrogenase iron-sulfur subunit; Reviewed

pfam13085
Location:40 → 146

Fer2_3; 2Fe-2S iron-sulfur cluster binding domain

pfam13534
Location:184 → 257

Fer4_17; 4Fe-4S dicluster domain