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    frmd7 FERM domain containing 7 [ Danio rerio (zebrafish) ]

    Gene ID: 751637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    frmd7provided by ZNC
    Official Full Name
    FERM domain containing 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060825-67
    See related
    Ensembl:ENSDARG00000068958 AllianceGenome:ZFIN:ZDB-GENE-060825-67
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153674
    Summary
    Predicted to enable cytoskeletal protein binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in developmental process. Predicted to be located in cytoskeleton and membrane. Human ortholog(s) of this gene implicated in congenital nystagmus 1. Orthologous to human FRMD7 (FERM domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See frmd7 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (43400351..43416692)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (43405181..43421089)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene septin 8a Neighboring gene cyclin I family, member 2 Neighboring gene serine/threonine protein kinase 26 Neighboring gene transmembrane protein 185

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC153674

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045356.2 → NP_001038821.2  FERM domain-containing protein 7

      Status: VALIDATED

      Source sequence(s)
      AL954767, CK353164
      UniProtKB/TrEMBL
      A0A8M1NAI2, A0A8M9PCT6, F1R8Z1
      Related
      ENSDARP00000119171.1, ENSDART00000141098.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      43400351..43416692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173898.5 → XP_005173955.3  FERM domain-containing protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BL62
      Related
      ENSDARP00000122496.1, ENSDART00000142234.2

    2. XM_021468907.2 → XP_021324582.1  FERM domain-containing protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PQL4
      Conserved Domains (3) summary
      cd13193
      Location:21 → 141
      FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
      pfam08736
      Location:134 → 169
      FA; FERM adjacent (FA)
      cl09511
      Location:1 → 34
      FERM_B-lobe; FERM domain B-lobe
    Nucleotide Protein
    Heading Accession and Version

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