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    fgfr2 fibroblast growth factor receptor 2 [ Danio rerio (zebrafish) ]

    Gene ID: 352940, updated on 9-Dec-2024

    Summary

    Official Symbol
    fgfr2provided by ZNC
    Official Full Name
    fibroblast growth factor receptor 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030323-1
    See related
    Ensembl:ENSDARG00000058115 AllianceGenome:ZFIN:ZDB-GENE-030323-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fgfr-2; fgfr2b; fgfr2c; fc56c05; wu:fc56c05
    Summary
    Enables fibroblast growth factor binding activity. Acts upstream of or within several processes, including cell proliferation in midbrain; determination of left/right symmetry; and pectoral fin development. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cranium; digestive system; mesoderm; nervous system; and trunk vasculature. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; breast cancer (multiple); gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See fgfr2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (46298560..46429433, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (46162095..46293000, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin/ISG15 ligase TRIM25-like Neighboring gene finTRIM family, member 69 Neighboring gene uncharacterized LOC137487443 Neighboring gene arginyltransferase 1 Neighboring gene transmembrane protein 63Ba

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibroblast growth factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fibroblast growth factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cartilage development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell proliferation in midbrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within determination of liver left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within determination of pancreatic left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within pectoral fin development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor receptor 2
    NP_001229933.1
    NP_001229934.1
    NP_001229935.1
    NP_840088.2
    XP_005169609.1
    XP_068081038.1
    XP_068081039.1
    XP_068081040.1
    XP_068081041.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243004.1NP_001229933.1  fibroblast growth factor receptor 2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      CU639430, CU862017, FP102866
      UniProtKB/Swiss-Prot
      Q8JG38
      UniProtKB/TrEMBL
      A0A8M1NYP8
      Related
      ENSDARP00000124761.1, ENSDART00000149125.3
      Conserved Domains (7) summary
      cd05857
      Location:164248
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:271360
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00409
      Location:174248
      IG; Immunoglobulin
      smart00410
      Location:263359
      IG_like; Immunoglobulin like
      cd05101
      Location:452764
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam07714
      Location:477753
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:48125
      Ig; Immunoglobulin domain
    2. NM_001243005.1NP_001229934.1  fibroblast growth factor receptor 2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks one coding exon and includes another, compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      CU639430, CU862017, FP102866
      UniProtKB/Swiss-Prot
      Q8JG38
      UniProtKB/TrEMBL
      A0A8M1P3W6, F1RBT3
      Related
      ENSDARP00000123845.1, ENSDART00000149602.2
      Conserved Domains (5) summary
      cd05857
      Location:164248
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00410
      Location:263357
      IG_like; Immunoglobulin like
      cd05101
      Location:450762
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam07714
      Location:475751
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:271358
      Ig; Immunoglobulin domain
    3. NM_001243006.1NP_001229935.1  fibroblast growth factor receptor 2 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001229935.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks a coding exon compared to variant 1. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      CU639430, CU862017, FP102866
      UniProtKB/Swiss-Prot
      Q8JG38
      UniProtKB/TrEMBL
      A4QN31
      Related
      ENSDARP00000089041.4, ENSDART00000098269.6
      Conserved Domains (5) summary
      cd05857
      Location:75159
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:182271
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00410
      Location:174270
      IG_like; Immunoglobulin like
      cd05101
      Location:363675
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam07714
      Location:388664
      Pkinase_Tyr; Protein tyrosine kinase
    4. NM_178303.3NP_840088.2  fibroblast growth factor receptor 2 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternative splice site in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      CU639430, CU862017, FP102866
      UniProtKB/Swiss-Prot
      Q8JG38
      UniProtKB/TrEMBL
      A0A8M1PE96, F1RBS5
      Related
      ENSDARP00000124472.1, ENSDART00000150061.3
      Conserved Domains (7) summary
      cd05857
      Location:164248
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:271360
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00409
      Location:174248
      IG; Immunoglobulin
      smart00410
      Location:263359
      IG_like; Immunoglobulin like
      cd05101
      Location:450762
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam07714
      Location:475751
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:48125
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      46298560..46429433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224940.1XP_068081041.1  fibroblast growth factor receptor 2 isoform X5

      UniProtKB/Swiss-Prot
      Q8JG38
    2. XM_068224939.1XP_068081040.1  fibroblast growth factor receptor 2 isoform X4

      UniProtKB/Swiss-Prot
      Q8JG38
    3. XM_068224937.1XP_068081038.1  fibroblast growth factor receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8JG38
    4. XM_005169552.5XP_005169609.1  fibroblast growth factor receptor 2 isoform X3

      UniProtKB/Swiss-Prot
      Q8JG38
      UniProtKB/TrEMBL
      A0A8M2BGU2
      Conserved Domains (5) summary
      cd05857
      Location:187271
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00410
      Location:286380
      IG_like; Immunoglobulin like
      cd05101
      Location:471783
      PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
      pfam07714
      Location:496772
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:294381
      Ig; Immunoglobulin domain
    5. XM_068224938.1XP_068081039.1  fibroblast growth factor receptor 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8JG38