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    si sucrase-isomaltase [ Danio rerio (zebrafish) ]

    Gene ID: 100148922, updated on 9-Dec-2024

    Summary

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    Official Symbol
    siprovided by ZNC
    Official Full Name
    sucrase-isomaltaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4622
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-4622
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mgam; fd42f04; fd44a09; wu:fd42f04; wu:fd44a09
    Summary
    Predicted to enable alpha-glucosidase activity and carbohydrate binding activity. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in apical plasma membrane. Human ortholog(s) of this gene implicated in congenital sucrase-isomaltase deficiency. Orthologous to several human genes including SI (sucrase-isomaltase). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 18
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (1761556..1929025)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (2028736..2117690)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488243 Neighboring gene SLIT and NTRK-like family, member 3a Neighboring gene protein unc-13 homolog C-like Neighboring gene protogenin homolog a (Gallus gallus)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cross-generational feeding of Bt (Bacillus thuringiensis)-maize to zebrafish (Danio rerio) showed no adverse effects on the parental or offspring generations. Sanden M, et al. Br J Nutr, 2013 Dec. PMID 23768244
    2. Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). Rocha F, et al. J Exp Biol, 2014 Apr 1. PMID 24363414
    3. Exogenous maltose enhances Zebrafish immunity to levofloxacin-resistant Vibrio alginolyticus. Jiang M, et al. Microb Biotechnol, 2020 Jul. PMID 32364684, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    maltase-glucoamylase, intestinal; sucrase-isomaltase, intestinal
    Names
    maltase-glucoamylase (alpha-glucosidase)
    sucrase-isomaltase (alpha-glucosidase)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      1761556..1929025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017351979.3 → XP_017207468.1  sucrase-isomaltase, intestinal

      UniProtKB/TrEMBL
      A0A8M6Z206
    Nucleotide Protein Strain
    Heading Accession and Version

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