ppp3r1b protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppp3r1bprovided by ZNC
Official Full Name: protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-18
See related: Ensembl:ENSDARG00000069360 AllianceGenome:ZFIN:ZDB-GENE-040912-18
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92169
Summary: Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity and phosphatase binding activity. Predicted to be involved in calcineurin-mediated signaling. Predicted to be part of calcineurin complex. Is expressed in several structures, including brain; heart; inner ear; liver; and swim bladder. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (51557789..51591364, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (50913994..50947565, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: calcineurin subunit B type 1b

Names: PPP3R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004553.1 → NP_001004553.1 calcineurin subunit B type 1b

See identical proteins and their annotated locations for NP_001004553.1

Status: PROVISIONAL

Source sequence(s)

BC081617

UniProtKB/TrEMBL

A0A8M1N281, Q66HZ0

Related

ENSDARP00000091642.2, ENSDART00000100869.4

Conserved Domains (1) summary

COG5126
Location:13 → 157

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

51557789..51591364 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160126.5 → XP_005160183.1 calcineurin subunit B type 1b isoform X1

UniProtKB/TrEMBL

A0A8M2B6Z6

Conserved Domains (2) summary

PTZ00184
Location:14 → 150

PTZ00184; calmodulin; Provisional

cd00051
Location:87 → 153

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...