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    gpd1l glycerol-3-phosphate dehydrogenase 1 like [ Danio rerio (zebrafish) ]

    Gene ID: 449663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpd1lprovided by ZNC
    Official Full Name
    glycerol-3-phosphate dehydrogenase 1 likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-220
    See related
    Ensembl:ENSDARG00000040024 AllianceGenome:ZFIN:ZDB-GENE-041010-220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92580; wu:fi13g03; wu:fi45b08
    Summary
    Predicted to enable NAD binding activity; glycerol-3-phosphate dehydrogenase (NAD+) activity; and protein homodimerization activity. Predicted to act upstream of or within carbohydrate metabolic process and glycerol-3-phosphate catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1L (glycerol-3-phosphate dehydrogenase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gpd1l in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (39247645..39267233, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (39297613..39317207, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zgc:77056 Neighboring gene transmembrane protein 42a Neighboring gene oxysterol binding protein-like 10b Neighboring gene STT3 oligosaccharyltransferase complex catalytic subunit B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Syntabulin, a motor protein linker, controls dorsal determination. Nojima H, et al. Development, 2010 Mar. PMID 20150281
    2. Waterborne microcystin-LR exposure induced chronic inflammatory response via MyD88-dependent toll-like receptor signaling pathway in male zebrafish. Lin W, et al. Sci Total Environ, 2020 Feb 1. PMID 31710851
    3. Gene expression profiling of zebrafish embryonic retinal pigment epithelium in vivo. Leung YF, et al. Invest Ophthalmol Vis Sci, 2007 Feb. PMID 17251491, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in NADH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycerol-3-phosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glycerol-3-phosphate dehydrogenase 1-like protein
    NP_001005934.1
    XP_068070044.1
    XP_068070045.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005934.2 → NP_001005934.1  glycerol-3-phosphate dehydrogenase 1-like protein

      See identical proteins and their annotated locations for NP_001005934.1

      Status: VALIDATED

      Source sequence(s)
      CR848829, CR925805
      UniProtKB/Swiss-Prot
      Q5XIZ6
      Related
      ENSDARP00000123149.2, ENSDART00000133642.4
      Conserved Domains (3) summary
      TIGR03376
      Location:6 → 344
      glycerol3P_DH; glycerol-3-phosphate dehydrogenase (NAD(+))
      pfam01210
      Location:6 → 170
      NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
      pfam07479
      Location:197 → 338
      NAD_Gly3P_dh_C; NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      39247645..39267233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213944.1 → XP_068070045.1  glycerol-3-phosphate dehydrogenase 1-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q5XIZ6

    2. XM_068213943.1 → XP_068070044.1  glycerol-3-phosphate dehydrogenase 1-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q5XIZ6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIZ6.1 GenPept UniProtKB/Swiss-Prot:Q5XIZ6

    Gene LinkOut

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